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==THE X-RAY STRUCTURE OF THE SAM-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE NIRE FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH SAH==
 
<StructureSection load='2ybo' size='340' side='right' caption='[[2ybo]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
==The x-ray structure of the SAM-dependent uroporphyrinogen III methyltransferase NirE from Pseudomonas aeruginosa in complex with SAH==
<StructureSection load='2ybo' size='340' side='right'caption='[[2ybo]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2ybo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YBO OCA]. <br>
<table><tr><td colspan='2'>[[2ybo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YBO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YBO FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ybq|2ybq]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ybo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ybo OCA], [https://pdbe.org/2ybo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ybo RCSB], [https://www.ebi.ac.uk/pdbsum/2ybo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ybo ProSAT]</span></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ybo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ybo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ybo RCSB], [http://www.ebi.ac.uk/pdbsum/2ybo PDBsum]</span></td></tr>
</table>
<table>
== Function ==
[https://www.uniprot.org/uniprot/P95417_PSEAI P95417_PSEAI]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Crystal structure of the heme d1 biosynthesis enzyme NirE in complex with its substrate reveals new insights into the catalytic mechanism of S-adenosyl-L-methionine-dependent uroporphyrinogen III methyltransferases.,Storbeck S, Saha S, Krausze J, Klink BU, Heinz DW, Layer G J Biol Chem. 2011 Jul 29;286(30):26754-67. Epub 2011 May 31. PMID:21632530<ref>PMID:21632530</ref>
Crystal structure of the heme d1 biosynthesis enzyme NirE in complex with its substrate reveals new insights into the catalytic mechanism of S-adenosyl-L-methionine-dependent uroporphyrinogen III methyltransferases.,Storbeck S, Saha S, Krausze J, Klink BU, Heinz DW, Layer G J Biol Chem. 2011 Jul 29;286(30):26754-67. Epub 2011 May 31. PMID:21632530<ref>PMID:21632530</ref>


From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 2ybo" style="background-color:#fffaf0;"></div>
==See Also==
*[[SAM-dependent methyltrasferase 3D structures|SAM-dependent methyltrasferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Pseudomonas aeruginosa]]
[[Category: Large Structures]]
[[Category: Uroporphyrinogen-III C-methyltransferase]]
[[Category: Pseudomonas aeruginosa PAO1]]
[[Category: Heinz, D W.]]
[[Category: Heinz DW]]
[[Category: Klink, B U.]]
[[Category: Klink BU]]
[[Category: Krausze, J.]]
[[Category: Krausze J]]
[[Category: Layer, G.]]
[[Category: Layer G]]
[[Category: Saha, S.]]
[[Category: Saha S]]
[[Category: Storbeck, S.]]
[[Category: Storbeck S]]
[[Category: Heme d1 biosynthesis]]
[[Category: Nire]]
[[Category: Sumt]]
[[Category: Transferase]]
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