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==CRYSTAL STRUCTURE OF NEURONAL LEUCINE RICH REPEAT PROTEIN AMIGO-1==
 
<StructureSection load='2xot' size='340' side='right' caption='[[2xot]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
==Crystal structure of neuronal leucine rich repeat protein AMIGO-1==
<StructureSection load='2xot' size='340' side='right'caption='[[2xot]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2xot]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XOT OCA]. <br>
<table><tr><td colspan='2'>[[2xot]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XOT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XOT FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xot OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xot RCSB], [http://www.ebi.ac.uk/pdbsum/2xot PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xot OCA], [https://pdbe.org/2xot PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xot RCSB], [https://www.ebi.ac.uk/pdbsum/2xot PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xot ProSAT]</span></td></tr>
<table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/AMGO1_MOUSE AMGO1_MOUSE] Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain (By similarity).[UniProtKB:Q80ZD7]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Crystal Structure and Role of Glycans and Dimerization in Folding of Neuronal Leucine-Rich Repeat Protein AMIGO-1.,Kajander T, Kuja-Panula J, Rauvala H, Goldman A J Mol Biol. 2011 Nov 11;413(5):1001-15. Epub 2011 Sep 29. PMID:21983541<ref>PMID:21983541</ref>
Crystal Structure and Role of Glycans and Dimerization in Folding of Neuronal Leucine-Rich Repeat Protein AMIGO-1.,Kajander T, Kuja-Panula J, Rauvala H, Goldman A J Mol Biol. 2011 Nov 11;413(5):1001-15. Epub 2011 Sep 29. PMID:21983541<ref>PMID:21983541</ref>


From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 2xot" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Goldman, A.]]
[[Category: Goldman A]]
[[Category: Kajander, T.]]
[[Category: Kajander T]]
[[Category: Kuja-Panula, J.]]
[[Category: Kuja-Panula J]]
[[Category: Rauvala, H.]]
[[Category: Rauvala H]]
[[Category: Cell adhesion]]
[[Category: Neurite growth regulation]]
[[Category: Neuronal protein]]
Retrieved from "https://proteopedia.org/2xot"