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==EVIDENCE FOR A TWO-METAL-ION-MECHANISM IN THE KDO-CYTIDYLYLTRANSFERASE KDSB==
 
<StructureSection load='2y6p' size='340' side='right' caption='[[2y6p]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
==Evidence for a Two-Metal-Ion-Mechanism in the Kdo- Cytidylyltransferase KdsB==
<StructureSection load='2y6p' size='340' side='right'caption='[[2y6p]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2y6p]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y6P OCA]. <br>
<table><tr><td colspan='2'>[[2y6p]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y6P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y6P FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CTP:CYTIDINE-5-TRIPHOSPHATE'>CTP</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CTP:CYTIDINE-5-TRIPHOSPHATE'>CTP</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y6p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y6p RCSB], [http://www.ebi.ac.uk/pdbsum/2y6p PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y6p OCA], [https://pdbe.org/2y6p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y6p RCSB], [https://www.ebi.ac.uk/pdbsum/2y6p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y6p ProSAT]</span></td></tr>
<table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KDSB_AQUAE KDSB_AQUAE] Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Evidence for a Two-Metal-Ion Mechanism in the Cytidyltransferase KdsB, an Enzyme Involved in Lipopolysaccharide Biosynthesis.,Schmidt H, Mesters JR, Wu J, Woodard RW, Hilgenfeld R, Mamat U PLoS One. 2011;6(8):e23231. Epub 2011 Aug 3. PMID:21826242<ref>PMID:21826242</ref>
Evidence for a Two-Metal-Ion Mechanism in the Cytidyltransferase KdsB, an Enzyme Involved in Lipopolysaccharide Biosynthesis.,Schmidt H, Mesters JR, Wu J, Woodard RW, Hilgenfeld R, Mamat U PLoS One. 2011;6(8):e23231. Epub 2011 Aug 3. PMID:21826242<ref>PMID:21826242</ref>


From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 2y6p" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: 3-deoxy-manno-octulosonate cytidylyltransferase]]
[[Category: Aquifex aeolicus]]
[[Category: Aquifex aeolicus]]
[[Category: Hilgenfeld, R.]]
[[Category: Large Structures]]
[[Category: Mamat, U.]]
[[Category: Hilgenfeld R]]
[[Category: Mesters, J R.]]
[[Category: Mamat U]]
[[Category: Schmidt, H.]]
[[Category: Mesters JR]]
[[Category: Lipid some]]
[[Category: Schmidt H]]
[[Category: Transferase]]
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