2y8t: Difference between revisions
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<StructureSection load='2y8t' size='340' side='right' caption='[[2y8t]], [[Resolution|resolution]] 1.95Å' scene=''> | ==Co-structure of AMA1 with a surface exposed region of RON2 from Toxoplasma gondii== | ||
<StructureSection load='2y8t' size='340' side='right'caption='[[2y8t]], [[Resolution|resolution]] 1.95Å' scene=''> | |||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2y8t]] is a 4 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2y8t]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y8T FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95Å</td></tr> | ||
<tr><td class="sblockLbl"><b>[[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9AT:(2S,3R)-2-AMINO-3-HYDROXY-BUTANAMIDE'>9AT</scene>, <scene name='pdbligand=BO3:BORIC+ACID'>BO3</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y8t OCA], [https://pdbe.org/2y8t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y8t RCSB], [https://www.ebi.ac.uk/pdbsum/2y8t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y8t ProSAT]</span></td></tr> | |||
</table> | |||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | == Function == | ||
<table> | [https://www.uniprot.org/uniprot/AMA1_TOXGV AMA1_TOXGV] Essential microneme protein that plays an important role in host cell invasion. Part of the moving junction (MJ) complex, a ringlike structure formed between the plasma membranes of the apical tip of the parasite and the target host cell. During invasion, the MJ migrates from the anterior to the posterior of the parasite, leading to internalization of the parasite into a parasitophorous vacuole (PV).<ref>PMID:11083833</ref> <ref>PMID:11087913</ref> <ref>PMID:16000372</ref> <ref>PMID:16102004</ref> <ref>PMID:16244709</ref> <ref>PMID:19247437</ref> <ref>PMID:20421941</ref> <ref>PMID:21205639</ref> <ref>PMID:22523242</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Host cell invasion by apicomplexan parasites: insights from the co-structure of AMA1 with a RON2 peptide.,Tonkin ML, Roques M, Lamarque MH, Pugniere M, Douguet D, Crawford J, Lebrun M, Boulanger MJ Science. 2011 Jul 22;333(6041):463-7. PMID:21778402<ref>PMID:21778402</ref> | Host cell invasion by apicomplexan parasites: insights from the co-structure of AMA1 with a RON2 peptide.,Tonkin ML, Roques M, Lamarque MH, Pugniere M, Douguet D, Crawford J, Lebrun M, Boulanger MJ Science. 2011 Jul 22;333(6041):463-7. PMID:21778402<ref>PMID:21778402</ref> | ||
From | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 2y8t" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Toxoplasma gondii]] | [[Category: Toxoplasma gondii]] | ||
[[Category: Boulanger | [[Category: Boulanger MJ]] | ||
[[Category: Crawford | [[Category: Crawford J]] | ||
[[Category: Douguet | [[Category: Douguet D]] | ||
[[Category: Lamarque | [[Category: Lamarque MH]] | ||
[[Category: Lebrun | [[Category: Lebrun M]] | ||
[[Category: Pugniere | [[Category: Pugniere M]] | ||
[[Category: Roques | [[Category: Roques M]] | ||
[[Category: Tonkin | [[Category: Tonkin ML]] | ||
Latest revision as of 08:10, 23 August 2023
Co-structure of AMA1 with a surface exposed region of RON2 from Toxoplasma gondii
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