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==tRNA-dihydrouridine synthase from Thermus thermophilus in complex with tRNA==
==tRNA-dihydrouridine synthase from Thermus thermophilus in complex with tRNA==
<StructureSection load='3b0v' size='340' side='right' caption='[[3b0v]], [[Resolution|resolution]] 3.51&Aring;' scene=''>
<StructureSection load='3b0v' size='340' side='right'caption='[[3b0v]], [[Resolution|resolution]] 3.51&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3b0v]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B0V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3B0V FirstGlance]. <br>
<table><tr><td colspan='2'>[[3b0v]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B0V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B0V FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.51&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=H2U:5,6-DIHYDROURIDINE-5-MONOPHOSPHATE'>H2U</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=H2U:5,6-DIHYDROURIDINE-5-MONOPHOSPHATE'>H2U</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3b0p|3b0p]], [[3b0u|3b0u]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b0v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b0v OCA], [https://pdbe.org/3b0v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b0v RCSB], [https://www.ebi.ac.uk/pdbsum/3b0v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b0v ProSAT]</span></td></tr>
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TTHA0016 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus])</td></tr>
</table>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b0v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b0v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3b0v RCSB], [http://www.ebi.ac.uk/pdbsum/3b0v PDBsum]</span></td></tr>
== Function ==
<table>
[https://www.uniprot.org/uniprot/DUSAL_THET8 DUSAL_THET8] Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs.[HAMAP-Rule:MF_02041]<ref>PMID:22123979</ref> <ref>PMID:25902496</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Molecular basis of dihydrouridine formation on tRNA.,Yu F, Tanaka Y, Yamashita K, Suzuki T, Nakamura A, Hirano N, Suzuki T, Yao M, Tanaka I Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19593-8. Epub 2011 Nov 28. PMID:22123979<ref>PMID:22123979</ref>
Molecular basis of dihydrouridine formation on tRNA.,Yu F, Tanaka Y, Yamashita K, Suzuki T, Nakamura A, Hirano N, Suzuki T, Yao M, Tanaka I Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19593-8. Epub 2011 Nov 28. PMID:22123979<ref>PMID:22123979</ref>


From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 3b0v" style="background-color:#fffaf0;"></div>
==See Also==
*[[Transfer RNA (tRNA)|Transfer RNA (tRNA)]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Thermus thermophilus]]
[[Category: Large Structures]]
[[Category: Nakamura, A.]]
[[Category: Thermus thermophilus HB8]]
[[Category: Tanaka, I.]]
[[Category: Nakamura A]]
[[Category: Tanaka, Y.]]
[[Category: Tanaka I]]
[[Category: Yamashita, K.]]
[[Category: Tanaka Y]]
[[Category: Yao, M.]]
[[Category: Yamashita K]]
[[Category: Yu, F.]]
[[Category: Yao M]]
[[Category: Oxidoreductase-rna complex]]
[[Category: Yu F]]
[[Category: Tim barrel]]
Retrieved from "https://proteopedia.org/3b0v"