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==NMR structure of SRA1p C-terminal domain==
==NMR structure of SRA1p C-terminal domain==
<StructureSection load='2mgx' size='340' side='right' caption='[[2mgx]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
<StructureSection load='2mgx' size='340' side='right'caption='[[2mgx]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2mgx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MGX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MGX FirstGlance]. <br>
<table><tr><td colspan='2'>[[2mgx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MGX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MGX FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SRA1, PP7684 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mgx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mgx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mgx RCSB], [http://www.ebi.ac.uk/pdbsum/2mgx PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mgx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mgx OCA], [https://pdbe.org/2mgx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mgx RCSB], [https://www.ebi.ac.uk/pdbsum/2mgx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mgx ProSAT]</span></td></tr>
<table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SRA1_HUMAN SRA1_HUMAN] Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis.<ref>PMID:10199399</ref> <ref>PMID:12943696</ref> <ref>PMID:14517287</ref> <ref>PMID:15351741</ref> <ref>PMID:15147866</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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The C-Terminal Domain of SRA1p Has a Fold More Similar to PRP18 than to an RRM and Does Not Directly Bind to the SRA1 RNA STR7 Region.,Bilinovich SM, Davis CM, Morris DL, Ray LA, Prokop JW, Buchan GJ, Leeper TC J Mol Biol. 2014 Apr 17;426(8):1753-65. doi: 10.1016/j.jmb.2014.01.007. Epub 2014, Jan 29. PMID:24486611<ref>PMID:24486611</ref>
The C-Terminal Domain of SRA1p Has a Fold More Similar to PRP18 than to an RRM and Does Not Directly Bind to the SRA1 RNA STR7 Region.,Bilinovich SM, Davis CM, Morris DL, Ray LA, Prokop JW, Buchan GJ, Leeper TC J Mol Biol. 2014 Apr 17;426(8):1753-65. doi: 10.1016/j.jmb.2014.01.007. Epub 2014, Jan 29. PMID:24486611<ref>PMID:24486611</ref>


From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 2mgx" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Bilinovich, S M.]]
[[Category: Large Structures]]
[[Category: Buchan, G J.]]
[[Category: Bilinovich SM]]
[[Category: Davis, C M.]]
[[Category: Buchan GJ]]
[[Category: Leeper, T C.]]
[[Category: Davis CM]]
[[Category: Morris, D L.]]
[[Category: Leeper TC]]
[[Category: Prokop, J W.]]
[[Category: Morris DL]]
[[Category: Ray, L A.]]
[[Category: Prokop JW]]
[[Category: Unknown function]]
[[Category: Ray LA]]
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