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==Solution structure of the E81 deletion mutant of the tandem UIMs of RAP80==
==Solution structure of the E81 deletion mutant of the tandem UIMs of RAP80==
<StructureSection load='2mkf' size='340' side='right' caption='[[2mkf]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2mkf' size='340' side='right'caption='[[2mkf]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2mkf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MKF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MKF FirstGlance]. <br>
<table><tr><td colspan='2'>[[2mkf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MKF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MKF FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3a1q|3a1q]], [[2mkg|2mkg]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">UIMC1, RAP80, RXRIP110 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkf OCA], [https://pdbe.org/2mkf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mkf RCSB], [https://www.ebi.ac.uk/pdbsum/2mkf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mkf ProSAT]</span></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mkf RCSB], [http://www.ebi.ac.uk/pdbsum/2mkf PDBsum]</span></td></tr>
</table>
<table>
== Function ==
[https://www.uniprot.org/uniprot/UIMC1_HUMAN UIMC1_HUMAN] Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.<ref>PMID:12080054</ref> <ref>PMID:17621610</ref> <ref>PMID:17643121</ref> <ref>PMID:17525340</ref> <ref>PMID:17525341</ref> <ref>PMID:17525342</ref> <ref>PMID:19261748</ref> <ref>PMID:19015238</ref> <ref>PMID:19202061</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Molecular Basis for Impaired DNA Damage Response Function Associated with the RAP80 DeltaE81 Defect.,Anamika A, Markin CJ, Rout MK, Spyracopoulos L J Biol Chem. 2014 Mar 13. PMID:24627472<ref>PMID:24627472</ref>
Molecular Basis for Impaired DNA Damage Response Function Associated with the RAP80 DeltaE81 Defect.,Anamika A, Markin CJ, Rout MK, Spyracopoulos L J Biol Chem. 2014 Mar 13. PMID:24627472<ref>PMID:24627472</ref>


From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 2mkf" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Anamika]]
[[Category: Anamika]]
[[Category: Markin, C J.]]
[[Category: Markin CJ]]
[[Category: Rout, M K.]]
[[Category: Rout MK]]
[[Category: Spyracopoulos, L.]]
[[Category: Spyracopoulos L]]
[[Category: Dna damage response]]
[[Category: Signaling protein]]
[[Category: Ubiquitin-interacting motif]]
[[Category: Uim]]
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