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==Crystal structure of 6-phosphogluconolactonase from Leishmania guyanensis==
==Crystal structure of 6-phosphogluconolactonase from Leishmania guyanensis==
<StructureSection load='3css' size='340' side='right' caption='[[3css]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='3css' size='340' side='right'caption='[[3css]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3css]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_braziliensis_mhom/br/75/m2904 Leishmania braziliensis mhom/br/75/m2904]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CSS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CSS FirstGlance]. <br>
<table><tr><td colspan='2'>[[3css]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_braziliensis_MHOM/BR/75/M2904 Leishmania braziliensis MHOM/BR/75/M2904]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CSS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CSS FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ch7|3ch7]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LbrM26_V2.2630, LbrM26_V2.2660 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=420245 Leishmania braziliensis MHOM/BR/75/M2904])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3css FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3css OCA], [https://pdbe.org/3css PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3css RCSB], [https://www.ebi.ac.uk/pdbsum/3css PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3css ProSAT]</span></td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Gluconolactonase Gluconolactonase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.17 3.1.1.17] </span></td></tr>
</table>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3css FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3css OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3css RCSB], [http://www.ebi.ac.uk/pdbsum/3css PDBsum]</span></td></tr>
== Function ==
<table>
[https://www.uniprot.org/uniprot/A4HFB4_LEIBR A4HFB4_LEIBR]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cs/3css_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cs/3css_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3css ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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Optimal description of a protein structure in terms of multiple groups undergoing TLS motion.,Painter J, Merritt EA Acta Crystallogr D Biol Crystallogr. 2006 Apr;62(Pt 4):439-50. Epub 2006, Mar 18. PMID:16552146<ref>PMID:16552146</ref>
Optimal description of a protein structure in terms of multiple groups undergoing TLS motion.,Painter J, Merritt EA Acta Crystallogr D Biol Crystallogr. 2006 Apr;62(Pt 4):439-50. Epub 2006, Mar 18. PMID:16552146<ref>PMID:16552146</ref>


From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 3css" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Gluconolactonase]]
[[Category: Large Structures]]
[[Category: Leishmania braziliensis mhom/br/75/m2904]]
[[Category: Leishmania braziliensis MHOM/BR/75/M2904]]
[[Category: Arakaki, T L.]]
[[Category: Arakaki TL]]
[[Category: Merritt, E A.]]
[[Category: Merritt EA]]
[[Category: SGPP, Structural Genomics of Pathogenic Protozoa Consortium.]]
[[Category: 6-phosphogluconolactonase]]
[[Category: Hydrolase]]
[[Category: Leishmaniasis]]
[[Category: Medical structural genomics of pathogenic protozoa consortium]]
[[Category: Sgpp]]
[[Category: Structural genomic]]

Latest revision as of 12:33, 30 August 2023

Crystal structure of 6-phosphogluconolactonase from Leishmania guyanensis

3css, resolution 1.70Å

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