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==Crystal structure of the phosphoribosyl pyrophosphate (PRPP) synthetase from Thermoplasma volcanium in complex with ADP.==
==Crystal structure of the phosphoribosyl pyrophosphate (PRPP) synthetase from Thermoplasma volcanium in complex with ADP.==
<StructureSection load='3lrt' size='340' side='right' caption='[[3lrt]], [[Resolution|resolution]] 1.53&Aring;' scene=''>
<StructureSection load='3lrt' size='340' side='right'caption='[[3lrt]], [[Resolution|resolution]] 1.53&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3lrt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermoplasma_volcanium Thermoplasma volcanium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LRT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LRT FirstGlance]. <br>
<table><tr><td colspan='2'>[[3lrt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermoplasma_volcanium Thermoplasma volcanium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LRT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LRT FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.534&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1u9y|1u9y]], [[1u9z|1u9z]], [[1ibs|1ibs]], [[2hcr|2hcr]], [[2h06|2h06]], [[2h07|2h07]], [[3lpn|3lpn]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">prs, TV0197, TVG0201915, TVN0197 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=50339 Thermoplasma volcanium])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lrt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lrt OCA], [https://pdbe.org/3lrt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lrt RCSB], [https://www.ebi.ac.uk/pdbsum/3lrt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lrt ProSAT]</span></td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribose-phosphate_diphosphokinase Ribose-phosphate diphosphokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.6.1 2.7.6.1] </span></td></tr>
</table>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lrt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lrt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lrt RCSB], [http://www.ebi.ac.uk/pdbsum/3lrt PDBsum]</span></td></tr>
== Function ==
<table>
[https://www.uniprot.org/uniprot/KPRS_THEVO KPRS_THEVO]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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The structures of Thermoplasma volcanium phosphoribosyl pyrophosphate synthetase bound to ribose-5-phosphate and ATP analogs.,Cherney MM, Cherney LT, Garen CR, James MN J Mol Biol. 2011 Nov 4;413(4):844-56. Epub 2011 Sep 21. PMID:21963988<ref>PMID:21963988</ref>
The structures of Thermoplasma volcanium phosphoribosyl pyrophosphate synthetase bound to ribose-5-phosphate and ATP analogs.,Cherney MM, Cherney LT, Garen CR, James MN J Mol Biol. 2011 Nov 4;413(4):844-56. Epub 2011 Sep 21. PMID:21963988<ref>PMID:21963988</ref>


From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 3lrt" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ribose-phosphate diphosphokinase]]
[[Category: Large Structures]]
[[Category: Thermoplasma volcanium]]
[[Category: Thermoplasma volcanium]]
[[Category: Cherney, L T.]]
[[Category: Cherney LT]]
[[Category: Cherney, M M.]]
[[Category: Cherney MM]]
[[Category: Garen, C R.]]
[[Category: Garen CR]]
[[Category: James, M N.G.]]
[[Category: James MNG]]
[[Category: Atp analog binding]]
[[Category: Atp-binding]]
[[Category: Kinase]]
[[Category: Metal-binding]]
[[Category: Nucleotide biosynthesis]]
[[Category: Nucleotide-binding]]
[[Category: Phosphoribosyl transferase]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/3lrt"