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==Structure of 6-pyruvoyltetrahydropterin synthase==
==Structure of 6-pyruvoyltetrahydropterin synthase==
<StructureSection load='3qn0' size='340' side='right' caption='[[3qn0]], [[Resolution|resolution]] 2.34&Aring;' scene=''>
<StructureSection load='3qn0' size='340' side='right'caption='[[3qn0]], [[Resolution|resolution]] 2.34&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3qn0]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecobd Ecobd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QN0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QN0 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3qn0]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_BL21(DE3) Escherichia coli BL21(DE3)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QN0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QN0 FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.34&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EcDH1_0923 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=469008 ECOBD])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/6-carboxytetrahydropterin_synthase 6-carboxytetrahydropterin synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.50 4.1.2.50] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qn0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qn0 OCA], [https://pdbe.org/3qn0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qn0 RCSB], [https://www.ebi.ac.uk/pdbsum/3qn0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qn0 ProSAT]</span></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qn0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qn0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qn0 RCSB], [http://www.ebi.ac.uk/pdbsum/3qn0 PDBsum]</span></td></tr>
</table>
<table>
== Function ==
[https://www.uniprot.org/uniprot/QUED_ECOLI QUED_ECOLI] Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde. Can also convert 6-pyruvoyltetrahydropterin (PPH4) and sepiapterin to CPH4; these 2 compounds are probably intermediates in the reaction from H2NTP.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Structural basis of a novel activity of bacterial 6-pyruvoyltetrahydropterin synthase homologues distinct from mammalian 6-pyruvoyltetrahydropterin synthase activity.,Seo KH, Zhuang N, Park YS, Park KH, Lee KH Acta Crystallogr D Biol Crystallogr. 2014 May;70(Pt 5):1212-23. doi:, 10.1107/S1399004714002016. Epub 2014 Apr 26. PMID:24816091<ref>PMID:24816091</ref>
Structural basis of a novel activity of bacterial 6-pyruvoyltetrahydropterin synthase homologues distinct from mammalian 6-pyruvoyltetrahydropterin synthase activity.,Seo KH, Zhuang N, Park YS, Park KH, Lee KH Acta Crystallogr D Biol Crystallogr. 2014 May;70(Pt 5):1212-23. doi:, 10.1107/S1399004714002016. Epub 2014 Apr 26. PMID:24816091<ref>PMID:24816091</ref>


From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 3qn0" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: 6-carboxytetrahydropterin synthase]]
[[Category: Large Structures]]
[[Category: Ecobd]]
[[Category: Lee KH]]
[[Category: Lee, K H.]]
[[Category: Seo KH]]
[[Category: Seo, K H.]]
[[Category: Zhuang NN]]
[[Category: Zhuang, N N.]]
[[Category: 6-pyruvoyltetrahydropterin synthase]]
[[Category: Bh4 synthase]]
[[Category: Lyase]]
[[Category: Sepiapterin]]
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