4qeo: Difference between revisions
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New page: '''Unreleased structure''' The entry 4qeo is ON HOLD Authors: Du, J., Li, S., Patel, D.J. Description: crystal structure of KRYPTONITE in complex with mCHH DNA, H3(1-15) peptide and SA... |
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The | ==crystal structure of KRYPTONITE in complex with mCHH DNA, H3(1-15) peptide and SAH== | ||
<StructureSection load='4qeo' size='340' side='right'caption='[[4qeo]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4qeo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana] and [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QEO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QEO FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qeo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qeo OCA], [https://pdbe.org/4qeo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qeo RCSB], [https://www.ebi.ac.uk/pdbsum/4qeo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qeo ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SUVH4_ARATH SUVH4_ARATH] Histone methyltransferase. Methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression. The silencing mechanism via DNA CpNpG methylation requires the targeting of chromomethylase CMT3 to methylated histones, probably through an interaction with an HP1-like adapter. By its function, KYP is directly required for the maintenance of the DNA CpNpG and asymmetric methylation. Involved in the silencing of transposable elements.<ref>PMID:11898023</ref> <ref>PMID:15457214</ref> <ref>PMID:15598823</ref> <ref>PMID:16277745</ref> <ref>PMID:16287862</ref> | |||
==See Also== | |||
*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Arabidopsis thaliana]] | |||
[[Category: Large Structures]] | |||
[[Category: Xenopus laevis]] | |||
[[Category: Du J]] | |||
[[Category: Li S]] | |||
[[Category: Patel DJ]] | |||
Latest revision as of 14:07, 13 March 2024
crystal structure of KRYPTONITE in complex with mCHH DNA, H3(1-15) peptide and SAH
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