4c6s: Difference between revisions

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==Crystal structure of the TIR domain from the Arabidopsis Thaliana disease resistance protein RRS1==
==Crystal structure of the TIR domain from the Arabidopsis Thaliana disease resistance protein RRS1==
<StructureSection load='4c6s' size='340' side='right' caption='[[4c6s]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
<StructureSection load='4c6s' size='340' side='right'caption='[[4c6s]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4c6s]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C6S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C6S FirstGlance]. <br>
<table><tr><td colspan='2'>[[4c6s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C6S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C6S FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.751&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4c6r|4c6r]], [[4c6t|4c6t]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c6s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c6s RCSB], [http://www.ebi.ac.uk/pdbsum/4c6s PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c6s OCA], [https://pdbe.org/4c6s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c6s RCSB], [https://www.ebi.ac.uk/pdbsum/4c6s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c6s ProSAT]</span></td></tr>
<table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/WRK52_ARATH WRK52_ARATH] Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element. Acts also as a disease resistance protein conferring resistance to Ralstonia solanacearum.
Cytoplasmic plant immune receptors recognize specific pathogen effector proteins and initiate effector-triggered immunity. In Arabidopsis, the immune receptors RPS4 and RRS1 are both required to activate defense to three different pathogens. We show that RPS4 and RRS1 physically associate. Crystal structures of the N-terminal Toll-interleukin-1 receptor/resistance (TIR) domains of RPS4 and RRS1, individually and as a heterodimeric complex (respectively at 2.05, 1.75, and 2.65 angstrom resolution), reveal a conserved TIR/TIR interaction interface. We show that TIR domain heterodimerization is required to form a functional RRS1/RPS4 effector recognition complex. The RPS4 TIR domain activates effector-independent defense, which is inhibited by the RRS1 TIR domain through the heterodimerization interface. Thus, RPS4 and RRS1 function as a receptor complex in which the two components play distinct roles in recognition and signaling.
 
Structural basis for assembly and function of a heterodimeric plant immune receptor.,Williams SJ, Sohn KH, Wan L, Bernoux M, Sarris PF, Segonzac C, Ve T, Ma Y, Saucet SB, Ericsson DJ, Casey LW, Lonhienne T, Winzor DJ, Zhang X, Coerdt A, Parker JE, Dodds PN, Kobe B, Jones JD Science. 2014 Apr 18;344(6181):299-303. doi: 10.1126/science.1247357. PMID:24744375<ref>PMID:24744375</ref>
 
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
</div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bernoux, M.]]
[[Category: Arabidopsis thaliana]]
[[Category: Dodds, P N.]]
[[Category: Large Structures]]
[[Category: Ericsson, D J.]]
[[Category: Bernoux M]]
[[Category: Jones, J D.G.]]
[[Category: Dodds PN]]
[[Category: Kobe, B.]]
[[Category: Ericsson DJ]]
[[Category: Ma, Y.]]
[[Category: Jones JDG]]
[[Category: Parker, J.]]
[[Category: Kobe B]]
[[Category: Sarris, P.]]
[[Category: Ma Y]]
[[Category: Saucet, S B.]]
[[Category: Parker J]]
[[Category: Segonzac, C.]]
[[Category: Sarris P]]
[[Category: Sohn, K H.]]
[[Category: Saucet SB]]
[[Category: Ve, T.]]
[[Category: Segonzac C]]
[[Category: Wan, L.]]
[[Category: Sohn KH]]
[[Category: Williams, S J.]]
[[Category: Ve T]]
[[Category: Zhang, X.]]
[[Category: Wan L]]
[[Category: Immune system]]
[[Category: Williams SJ]]
[[Category: Plant tir domain]]
[[Category: Zhang X]]
[[Category: Signal transduction]]

Latest revision as of 07:18, 1 May 2024

Crystal structure of the TIR domain from the Arabidopsis Thaliana disease resistance protein RRS1

4c6s, resolution 1.75Å

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