2c5c: Difference between revisions

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[[Image:2c5c.gif|left|200px]]<br />
<applet load="2c5c" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2c5c, resolution 2.94&Aring;" />
'''SHIGA-LIKE TOXIN 1 B SUBUNIT COMPLEXED WITH A BIVALENT INHIBITOR'''<br />


==About this Structure==
==Shiga-like toxin 1 B subunit complexed with a bivalent inhibitor==
2C5C is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Bacillus_phage_h1 Bacillus phage h1]] with GLA, SO4 and S10 as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2C5C OCA]].  
<StructureSection load='2c5c' size='340' side='right'caption='[[2c5c]], [[Resolution|resolution]] 2.94&Aring;' scene=''>
[[Category: Bacillus phage h1]]
== Structural highlights ==
[[Category: Single protein]]
<table><tr><td colspan='2'>[[2c5c]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Phage_h30 Phage h30]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C5C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C5C FirstGlance]. <br>
[[Category: Dodd, R.B.]]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.94&#8491;</td></tr>
[[Category: Read, R.J.]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=S10:DIETHYL+PROPANE-1,3-DIYLBISCARBAMATE'>S10</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
[[Category: GLA]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c5c OCA], [https://pdbe.org/2c5c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c5c RCSB], [https://www.ebi.ac.uk/pdbsum/2c5c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c5c ProSAT]</span></td></tr>
[[Category: S10]]
</table>
[[Category: SO4]]
== Function ==
[[Category: bacterial exotoxin]]
[https://www.uniprot.org/uniprot/STXB_BPH30 STXB_BPH30] The B subunit is responsible for the binding of the holotoxin to specific receptors on the target cell surface, such as globotriaosylceramide (Gb3) in human intestinal microvilli.
[[Category: bivalent ligand]]
== Evolutionary Conservation ==
[[Category: gb3 binding activity]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: ob fold]]
Check<jmol>
[[Category: protein-carbohydrate recognition]]
  <jmolCheckbox>
[[Category: toxin]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c5/2c5c_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c5c ConSurf].
<div style="clear:both"></div>


''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 16:58:32 2007''
==See Also==
*[[Shiga toxin 3D structures|Shiga toxin 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Phage h30]]
[[Category: Dodd RB]]
[[Category: Read RJ]]
Retrieved from "https://proteopedia.org/2c5c"