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==Crystal Structure of Salmo Salar p38alpha==
==Crystal Structure of Salmo Salar p38alpha==
<StructureSection load='3oht' size='340' side='right' caption='[[3oht]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='3oht' size='340' side='right'caption='[[3oht]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3oht]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmo_salar Salmo salar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OHT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OHT FirstGlance]. <br>
<table><tr><td colspan='2'>[[3oht]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmo_salar Salmo salar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OHT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OHT FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1N1:N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE'>1N1</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">p38a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8030 Salmo salar])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1N1:N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE'>1N1</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3oht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oht OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3oht RCSB], [http://www.ebi.ac.uk/pdbsum/3oht PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oht OCA], [https://pdbe.org/3oht PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oht RCSB], [https://www.ebi.ac.uk/pdbsum/3oht PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oht ProSAT]</span></td></tr>
<table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A9UJZ9_SALSA A9UJZ9_SALSA]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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p38alpha MAP kinase dimers with swapped activation segments and a novel catalytic loop conformation.,Rothweiler U, Aberg E, Johnson KA, Hansen TE, Jorgensen JB, Engh RA J Mol Biol. 2011 Aug 12;411(2):474-85. Epub 2011 Jun 15. PMID:21699901<ref>PMID:21699901</ref>
p38alpha MAP kinase dimers with swapped activation segments and a novel catalytic loop conformation.,Rothweiler U, Aberg E, Johnson KA, Hansen TE, Jorgensen JB, Engh RA J Mol Biol. 2011 Aug 12;411(2):474-85. Epub 2011 Jun 15. PMID:21699901<ref>PMID:21699901</ref>


From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 3oht" style="background-color:#fffaf0;"></div>
==See Also==
*[[Mitogen-activated protein kinase 3D structures|Mitogen-activated protein kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Salmo salar]]
[[Category: Salmo salar]]
[[Category: Engh, R A.]]
[[Category: Engh RA]]
[[Category: Johnson, K.]]
[[Category: Johnson K]]
[[Category: Rothweiler, U.]]
[[Category: Rothweiler U]]
[[Category: Kinase serine/threonine-protein kinase transferase]]
[[Category: Transferase-transferase inhibitor complex]]