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==Trypanosoma cruzi trans-sialidase-like inactive isoform (including the natural mutation Tyr342His) in complex with lactose==
==Trypanosoma cruzi trans-sialidase-like inactive isoform (including the natural mutation Tyr342His) in complex with lactose==
<StructureSection load='3pjq' size='340' side='right' caption='[[3pjq]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='3pjq' size='340' side='right'caption='[[3pjq]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3pjq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PJQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PJQ FirstGlance]. <br>
<table><tr><td colspan='2'>[[3pjq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PJQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PJQ FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LBT:ALPHA-LACTOSE'>LBT</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1s0i|1s0i]], [[1s0j|1s0j]], [[1ms0|1ms0]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PRD_900008:alpha-lactose'>PRD_900008</scene></td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pjq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pjq OCA], [https://pdbe.org/3pjq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pjq RCSB], [https://www.ebi.ac.uk/pdbsum/3pjq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pjq ProSAT]</span></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pjq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pjq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pjq RCSB], [http://www.ebi.ac.uk/pdbsum/3pjq PDBsum]</span></td></tr>
</table>
<table>
== Function ==
[https://www.uniprot.org/uniprot/Q26966_TRYCR Q26966_TRYCR]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Crystal structure of an enzymatically inactive trans-sialidase-like lectin from Trypanosoma cruzi: The carbohydrate binding mechanism involves residual sialidase activity.,Oppezzo P, Obal G, Baraibar MA, Pritsch O, Alzari PM, Buschiazzo A Biochim Biophys Acta. 2011 Apr 30. PMID:21570497<ref>PMID:21570497</ref>
Crystal structure of an enzymatically inactive trans-sialidase-like lectin from Trypanosoma cruzi: The carbohydrate binding mechanism involves residual sialidase activity.,Oppezzo P, Obal G, Baraibar MA, Pritsch O, Alzari PM, Buschiazzo A Biochim Biophys Acta. 2011 Apr 30. PMID:21570497<ref>PMID:21570497</ref>


From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 3pjq" style="background-color:#fffaf0;"></div>
==See Also==
*[[Neuraminidase 3D structures|Neuraminidase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Exo-alpha-sialidase]]
[[Category: Large Structures]]
[[Category: Trypanosoma cruzi]]
[[Category: Trypanosoma cruzi]]
[[Category: Alzari, P M.]]
[[Category: Alzari PM]]
[[Category: Baraibar, M.]]
[[Category: Baraibar M]]
[[Category: Buschiazzo, A.]]
[[Category: Buschiazzo A]]
[[Category: Obal, G.]]
[[Category: Obal G]]
[[Category: Oppezzo, P.]]
[[Category: Oppezzo P]]
[[Category: Pritsch, O.]]
[[Category: Pritsch O]]
[[Category: Beta-propeller]]
[[Category: Lactose]]
[[Category: Lectin / similar to actve trans-sialidase]]
[[Category: Sugar binding protein]]
Retrieved from "https://proteopedia.org/3pjq"