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==Engineered Thermoplasma Acidophilum F3 factor mimics human aminopeptidase N (APN) as a target for anticancer drug development==
==Engineered Thermoplasma Acidophilum F3 factor mimics human aminopeptidase N (APN) as a target for anticancer drug development==
<StructureSection load='3q7j' size='340' side='right' caption='[[3q7j]], [[Resolution|resolution]] 2.91&Aring;' scene=''>
<StructureSection load='3q7j' size='340' side='right'caption='[[3q7j]], [[Resolution|resolution]] 2.91&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3q7j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q7J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q7J FirstGlance]. <br>
<table><tr><td colspan='2'>[[3q7j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermoplasma_acidophilum_DSM_1728 Thermoplasma acidophilum DSM 1728]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q7J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q7J FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FBO:L-PHENYLALANYL-N6-[(BENZYLOXY)CARBONYL]-N1-HYDROXY-L-LYSINAMIDE'>FBO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.91&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">O93655, Ta0815, trf3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2303 Thermoplasma acidophilum])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FBO:L-PHENYLALANYL-N6-[(BENZYLOXY)CARBONYL]-N1-HYDROXY-L-LYSINAMIDE'>FBO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q7j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3q7j RCSB], [http://www.ebi.ac.uk/pdbsum/3q7j PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q7j OCA], [https://pdbe.org/3q7j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q7j RCSB], [https://www.ebi.ac.uk/pdbsum/3q7j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q7j ProSAT]</span></td></tr>
<table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TRF3_THEAC TRF3_THEAC] Proteases F1, F2 and F3 degrade oligopeptides produced by Tricorn (themselves probably produced by the proteasome), yielding free amino acids.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Engineered Thermoplasma acidophilum factor F3 mimics human aminopeptidase N (APN) as a target for anticancer drug development.,Su J, Wang Q, Feng J, Zhang C, Zhu D, Wei T, Xu W, Gu L Bioorg Med Chem. 2011 May 1;19(9):2991-6. Epub 2011 Mar 21. PMID:21493078<ref>PMID:21493078</ref>
Engineered Thermoplasma acidophilum factor F3 mimics human aminopeptidase N (APN) as a target for anticancer drug development.,Su J, Wang Q, Feng J, Zhang C, Zhu D, Wei T, Xu W, Gu L Bioorg Med Chem. 2011 May 1;19(9):2991-6. Epub 2011 Mar 21. PMID:21493078<ref>PMID:21493078</ref>


From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 3q7j" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Thermoplasma acidophilum]]
[[Category: Large Structures]]
[[Category: Feng, J.]]
[[Category: Thermoplasma acidophilum DSM 1728]]
[[Category: Gu, L.]]
[[Category: Feng J]]
[[Category: Su, J.]]
[[Category: Gu L]]
[[Category: Wang, Q.]]
[[Category: Su J]]
[[Category: We, T.]]
[[Category: Wang Q]]
[[Category: Xu, W.]]
[[Category: We T]]
[[Category: Zhang, C.]]
[[Category: Xu W]]
[[Category: Zhu, D.]]
[[Category: Zhang C]]
[[Category: Aminopeptidase]]
[[Category: Zhu D]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Inhibitor binding]]
[[Category: Inhibitor fbo]]
[[Category: Trf3]]
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