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==Bovine GRK2 in complex with Gbetagamma subunits==
==Bovine GRK2 in complex with Gbetagamma subunits==
<StructureSection load='3psc' size='340' side='right' caption='[[3psc]], [[Resolution|resolution]] 2.67&Aring;' scene=''>
<StructureSection load='3psc' size='340' side='right'caption='[[3psc]], [[Resolution|resolution]] 2.67&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3psc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PSC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PSC FirstGlance]. <br>
<table><tr><td colspan='2'>[[3psc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PSC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PSC FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CMT:O-METHYLCYSTEINE'>CMT</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.67&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1omw|1omw]], [[3pvu|3pvu]], [[3pvw|3pvw]], [[3krw|3krw]], [[3krx|3krx]], [[3cik|3cik]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMT:O-METHYLCYSTEINE'>CMT</scene></td></tr>
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ADRBK1, GRK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 Bos taurus]), GNB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 Bos taurus]), GNG2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 Bos taurus])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3psc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3psc OCA], [https://pdbe.org/3psc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3psc RCSB], [https://www.ebi.ac.uk/pdbsum/3psc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3psc ProSAT]</span></td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/[Beta-adrenergic-receptor]_kinase [Beta-adrenergic-receptor] kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.15 2.7.11.15] </span></td></tr>
</table>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3psc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3psc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3psc RCSB], [http://www.ebi.ac.uk/pdbsum/3psc PDBsum]</span></td></tr>
== Function ==
<table>
[https://www.uniprot.org/uniprot/ARBK1_BOVIN ARBK1_BOVIN] Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Molecular Mechanism of Selectivity Among G Protein-Coupled Receptor Kinase 2 Inhibitors.,Thal DM, Yeow RY, Schoenau C, Huber J, Tesmer JJ Mol Pharmacol. 2011 May 19. PMID:21596927<ref>PMID:21596927</ref>
Molecular Mechanism of Selectivity Among G Protein-Coupled Receptor Kinase 2 Inhibitors.,Thal DM, Yeow RY, Schoenau C, Huber J, Tesmer JJ Mol Pharmacol. 2011 May 19. PMID:21596927<ref>PMID:21596927</ref>


From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 3psc" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Guanine nucleotide-binding protein|Guanine nucleotide-binding protein]]
*[[Beta adrenergic receptor kinase 3D structures|Beta adrenergic receptor kinase 3D structures]]
*[[Transducin 3D structures|Transducin 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Tesmer, J J.]]
[[Category: Large Structures]]
[[Category: Thal, D M.]]
[[Category: Tesmer JJ]]
[[Category: Atp-binding]]
[[Category: Thal DM]]
[[Category: Kinase]]
[[Category: Membrane]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Transferase-signaling protein complex]]
Retrieved from "https://proteopedia.org/3psc"