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==Crystal structure of histo-aspartic protease (HAP) zymogen from Plasmodium falciparum==
==Crystal structure of histo-aspartic protease (HAP) zymogen from Plasmodium falciparum==
<StructureSection load='3qvc' size='340' side='right' caption='[[3qvc]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='3qvc' size='340' side='right'caption='[[3qvc]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3qvc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QVC FirstGlance]. <br>
<table><tr><td colspan='2'>[[3qvc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QVC FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3qvi|3qvi]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">hap ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 Plasmodium falciparum])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qvc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qvc OCA], [https://pdbe.org/3qvc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qvc RCSB], [https://www.ebi.ac.uk/pdbsum/3qvc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qvc ProSAT]</span></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qvc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qvc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qvc RCSB], [http://www.ebi.ac.uk/pdbsum/3qvc PDBsum]</span></td></tr>
</table>
<table>
== Function ==
[https://www.uniprot.org/uniprot/PLM3_PLAFX PLM3_PLAFX] During the asexual blood stage, catalyzes the cleavage of denatured host hemoglobin (Hb) or globins (PubMed:11782538). Digestion of host Hb is an essential step which provides the parasite with amino acids for protein synthesis, and regulates osmolarity (Probable).<ref>PMID:11782538</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Structural Insights into the Activation and Inhibition of Histo-Aspartic Protease from Plasmodium falciparum.,Bhaumik P, Xiao H, Hidaka K, Gustchina A, Kiso Y, Yada RY, Wlodawer A Biochemistry. 2011 Oct 18;50(41):8862-79. Epub 2011 Sep 26. PMID:21928835<ref>PMID:21928835</ref>
Structural Insights into the Activation and Inhibition of Histo-Aspartic Protease from Plasmodium falciparum.,Bhaumik P, Xiao H, Hidaka K, Gustchina A, Kiso Y, Yada RY, Wlodawer A Biochemistry. 2011 Oct 18;50(41):8862-79. Epub 2011 Sep 26. PMID:21928835<ref>PMID:21928835</ref>


From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 3qvc" style="background-color:#fffaf0;"></div>
==See Also==
*[[Plasmepsin|Plasmepsin]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Plasmodium falciparum]]
[[Category: Plasmodium falciparum]]
[[Category: Bhaumik, P.]]
[[Category: Bhaumik P]]
[[Category: Gustchina, A.]]
[[Category: Gustchina A]]
[[Category: Wlodawer, A.]]
[[Category: Wlodawer A]]
[[Category: Aspartic protease]]
[[Category: Hap]]
[[Category: Histo-aspartic protease]]
[[Category: Hydrolase]]
[[Category: Malaria]]
[[Category: Plasmepsin]]
[[Category: Zymogen]]
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