3rsn: Difference between revisions
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==Crystal Structure of the N-terminal region of Human Ash2L== | ==Crystal Structure of the N-terminal region of Human Ash2L== | ||
<StructureSection load='3rsn' size='340' side='right' caption='[[3rsn]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='3rsn' size='340' side='right'caption='[[3rsn]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3rsn]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3rsn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RSN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RSN FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | ||
<tr><td class="sblockLbl"><b>[[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rsn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rsn OCA], [https://pdbe.org/3rsn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rsn RCSB], [https://www.ebi.ac.uk/pdbsum/3rsn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rsn ProSAT]</span></td></tr> | |||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </table> | ||
<table> | == Function == | ||
[https://www.uniprot.org/uniprot/ASH2L_HUMAN ASH2L_HUMAN] Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis.<ref>PMID:12670868</ref> <ref>PMID:19556245</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 14: | Line 16: | ||
Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding.,Chen Y, Wan B, Wang KC, Cao F, Yang Y, Protacio A, Dou Y, Chang HY, Lei M EMBO Rep. 2011 Jun 10. doi: 10.1038/embor.2011.101. PMID:21660059<ref>PMID:21660059</ref> | Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding.,Chen Y, Wan B, Wang KC, Cao F, Yang Y, Protacio A, Dou Y, Chang HY, Lei M EMBO Rep. 2011 Jun 10. doi: 10.1038/embor.2011.101. PMID:21660059<ref>PMID:21660059</ref> | ||
From | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 3rsn" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
*[[Histone methyltransferase|Histone methyltransferase]] | *[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
| Line 24: | Line 27: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Cao | [[Category: Large Structures]] | ||
[[Category: Chang | [[Category: Cao F]] | ||
[[Category: Chen | [[Category: Chang HY]] | ||
[[Category: Dou | [[Category: Chen Y]] | ||
[[Category: Lei | [[Category: Dou Y]] | ||
[[Category: Protacio | [[Category: Lei M]] | ||
[[Category: Wan | [[Category: Protacio A]] | ||
[[Category: Wang | [[Category: Wan B]] | ||
[[Category: Yang | [[Category: Wang KC]] | ||
[[Category: Yang Y]] | |||
Latest revision as of 10:24, 6 November 2024
Crystal Structure of the N-terminal region of Human Ash2L
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