3srk: Difference between revisions
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==A new class of suicide inhibitor blocks nucleotide binding to pyruvate kinase== | ==A new class of suicide inhibitor blocks nucleotide binding to pyruvate kinase== | ||
<StructureSection load='3srk' size='340' side='right' caption='[[3srk]], [[Resolution|resolution]] 2.65Å' scene=''> | <StructureSection load='3srk' size='340' side='right'caption='[[3srk]], [[Resolution|resolution]] 2.65Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3srk]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3srk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_mexicana Leishmania mexicana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SRK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SRK FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=LSA:1,2-BENZISOTHIAZOL-3(2H)-ONE+1,1-DIOXIDE'>LSA</scene>, <scene name='pdbligand=PTK:PYRENE-1,3,6,8-TETRASULFONIC+ACID'>PTK</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=LSA:1,2-BENZISOTHIAZOL-3(2H)-ONE+1,1-DIOXIDE'>LSA</scene>, <scene name='pdbligand=PTK:PYRENE-1,3,6,8-TETRASULFONIC+ACID'>PTK</scene></td></tr> | |||
<tr | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3srk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3srk OCA], [https://pdbe.org/3srk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3srk RCSB], [https://www.ebi.ac.uk/pdbsum/3srk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3srk ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
<table> | [https://www.uniprot.org/uniprot/KPYK_LEIME KPYK_LEIME] | ||
==See Also== | ==See Also== | ||
*[[Pyruvate | *[[Pyruvate kinase 3D structures|Pyruvate kinase 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Leishmania mexicana]] | [[Category: Leishmania mexicana]] | ||
[[Category: Auld DS]] | |||
[[Category: Auld | [[Category: Blackburn EA]] | ||
[[Category: Blackburn | [[Category: Boxer M]] | ||
[[Category: Boxer | [[Category: Fothergill-Gilmore LA]] | ||
[[Category: Fothergill-Gilmore | [[Category: McNae IW]] | ||
[[Category: McNae | [[Category: Michels PAM]] | ||
[[Category: Michels | [[Category: Morgan HP]] | ||
[[Category: Morgan | [[Category: Shen M]] | ||
[[Category: Shen | [[Category: Walkinshaw MD]] | ||
[[Category: Walkinshaw | [[Category: Walsh M]] | ||
[[Category: Walsh | [[Category: Wear MA]] | ||
[[Category: Wear | |||
Latest revision as of 06:10, 17 October 2024
A new class of suicide inhibitor blocks nucleotide binding to pyruvate kinase
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