3sx0: Difference between revisions
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==Crystal structure of Dot1l in complex with a brominated SAH analog== | ==Crystal structure of Dot1l in complex with a brominated SAH analog== | ||
<StructureSection load='3sx0' size='340' side='right' caption='[[3sx0]], [[Resolution|resolution]] 2.28Å' scene=''> | <StructureSection load='3sx0' size='340' side='right'caption='[[3sx0]], [[Resolution|resolution]] 2.28Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3sx0]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3sx0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SX0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SX0 FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SX0:(2S)-2-AMINO-4-({[(2S,3S,4R,5R)-5-(4-AMINO-5-BROMO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL}SULFANYL)BUTANOIC+ACID+(NON-PREFERRED+NAME)'>SX0</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.28Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SX0:(2S)-2-AMINO-4-({[(2S,3S,4R,5R)-5-(4-AMINO-5-BROMO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL}SULFANYL)BUTANOIC+ACID+(NON-PREFERRED+NAME)'>SX0</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | |||
<tr | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sx0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sx0 OCA], [https://pdbe.org/3sx0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sx0 RCSB], [https://www.ebi.ac.uk/pdbsum/3sx0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sx0 ProSAT]</span></td></tr> | ||
</table> | |||
<table> | == Function == | ||
[https://www.uniprot.org/uniprot/DOT1L_HUMAN DOT1L_HUMAN] Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA. | |||
==See Also== | ==See Also== | ||
*[[Histone methyltransferase|Histone methyltransferase]] | *[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith | [[Category: Large Structures]] | ||
[[Category: Bountra | [[Category: Arrowsmith CH]] | ||
[[Category: Brown | [[Category: Bountra C]] | ||
[[Category: Edwards | [[Category: Brown PJ]] | ||
[[Category: Li | [[Category: Edwards AM]] | ||
[[Category: Nguyen | [[Category: Li Y]] | ||
[[Category: Nguyen KT]] | |||
[[Category: Schapira | [[Category: Schapira M]] | ||
[[Category: Smil | [[Category: Smil D]] | ||
[[Category: Tempel | [[Category: Tempel W]] | ||
[[Category: Vedadi | [[Category: Vedadi M]] | ||
[[Category: Weigelt | [[Category: Weigelt J]] | ||
[[Category: Wernimont | [[Category: Wernimont AK]] | ||
[[Category: Yu | [[Category: Yu W]] | ||
Latest revision as of 13:10, 14 March 2024
Crystal structure of Dot1l in complex with a brominated SAH analog
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