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==Crystal structure of the DHR-2 domain of DOCK8 in complex with Cdc42 (T17N mutant)==
==Crystal structure of the DHR-2 domain of DOCK8 in complex with Cdc42 (T17N mutant)==
<StructureSection load='3vhl' size='340' side='right' caption='[[3vhl]], [[Resolution|resolution]] 2.08&Aring;' scene=''>
<StructureSection load='3vhl' size='340' side='right'caption='[[3vhl]], [[Resolution|resolution]] 2.08&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3vhl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VHL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VHL FirstGlance]. <br>
<table><tr><td colspan='2'>[[3vhl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VHL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VHL FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.085&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Dock8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), CDC42 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vhl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vhl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vhl RCSB], [http://www.ebi.ac.uk/pdbsum/3vhl PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vhl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vhl OCA], [https://pdbe.org/3vhl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vhl RCSB], [https://www.ebi.ac.uk/pdbsum/3vhl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vhl ProSAT]</span></td></tr>
<table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DOCK8_MOUSE DOCK8_MOUSE] Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses.,Harada Y, Tanaka Y, Terasawa M, Pieczyk M, Habiro K, Katakai T, Hanawa-Suetsugu K, Kukimoto-Niino M, Nishizaki T, Shirouzu M, Duan X, Uruno T, Nishikimi A, Sanematsu F, Yokoyama S, Stein JV, Kinashi T, Fukui Y Blood. 2012 May 10;119(19):4451-61. Epub 2012 Mar 28. PMID:22461490<ref>PMID:22461490</ref>
DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses.,Harada Y, Tanaka Y, Terasawa M, Pieczyk M, Habiro K, Katakai T, Hanawa-Suetsugu K, Kukimoto-Niino M, Nishizaki T, Shirouzu M, Duan X, Uruno T, Nishikimi A, Sanematsu F, Yokoyama S, Stein JV, Kinashi T, Fukui Y Blood. 2012 May 10;119(19):4451-61. Epub 2012 Mar 28. PMID:22461490<ref>PMID:22461490</ref>


From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 3vhl" style="background-color:#fffaf0;"></div>
==See Also==
*[[Dedicator of cytokinesis protein 3D structures|Dedicator of cytokinesis protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Fukui, Y.]]
[[Category: Fukui Y]]
[[Category: Hanawa-Suetsugu, K.]]
[[Category: Hanawa-Suetsugu K]]
[[Category: Kukimoto-Niino, M.]]
[[Category: Kukimoto-Niino M]]
[[Category: Nishizak, T.]]
[[Category: Nishizak T]]
[[Category: Shirouzu, M.]]
[[Category: Shirouzu M]]
[[Category: Terada, T.]]
[[Category: Terada T]]
[[Category: Yokoyama, S.]]
[[Category: Yokoyama S]]
[[Category: Gtpase]]
[[Category: Guanine nucleotide exchang factor]]
[[Category: Signal transduction]]
[[Category: Signaling protein]]
Retrieved from "https://proteopedia.org/3vhl"