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==Crystal Structure of the Acyltransferase Domain of the Iterative Polyketide Synthase in Enediyne Biosynthesis Reveals the Molecular Basis of Substrate Specificity==
==Crystal Structure of the Acyltransferase Domain of the Iterative Polyketide Synthase in Enediyne Biosynthesis Reveals the Molecular Basis of Substrate Specificity==
<StructureSection load='4amn' size='340' side='right' caption='[[4amn]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
<StructureSection load='4amn' size='340' side='right'caption='[[4amn]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4amn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Micromonospora_chersina Micromonospora chersina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AMN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AMN FirstGlance]. <br>
<table><tr><td colspan='2'>[[4amn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Micromonospora_chersina Micromonospora chersina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AMN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AMN FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4amm|4amm]], [[4amo|4amo]], [[4amp|4amp]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4amn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4amn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4amn RCSB], [http://www.ebi.ac.uk/pdbsum/4amn PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4amn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4amn OCA], [https://pdbe.org/4amn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4amn RCSB], [https://www.ebi.ac.uk/pdbsum/4amn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4amn ProSAT]</span></td></tr>
<table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q84HI8_9ACTN Q84HI8_9ACTN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Crystal structure of the acyltransferase domain of the iterative polyketide synthase in enediyne biosynthesis.,Liew CW, Nilsson M, Chen MW, Sun H, Cornvik T, Liang ZX, Lescar J J Biol Chem. 2012 May 15. PMID:22589546<ref>PMID:22589546</ref>
Crystal structure of the acyltransferase domain of the iterative polyketide synthase in enediyne biosynthesis.,Liew CW, Nilsson M, Chen MW, Sun H, Cornvik T, Liang ZX, Lescar J J Biol Chem. 2012 May 15. PMID:22589546<ref>PMID:22589546</ref>


From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4amn" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Micromonospora chersina]]
[[Category: Micromonospora chersina]]
[[Category: Lescar, J.]]
[[Category: Lescar J]]
[[Category: Liew, C W.]]
[[Category: Liew CW]]
[[Category: Acyltransferase]]
[[Category: Dynemicin]]
[[Category: Polyketide synthase]]
[[Category: Transferase]]