4eq6: Difference between revisions

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==The crystal structure of Psy3-Csm2 complex from budding yeast==
==The crystal structure of Psy3-Csm2 complex from budding yeast==
<StructureSection load='4eq6' size='340' side='right' caption='[[4eq6]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='4eq6' size='340' side='right'caption='[[4eq6]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4eq6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EQ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EQ6 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4eq6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EQ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EQ6 FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CSM2, YIL132C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), PSY3, YLR376C, L8039.17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eq6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4eq6 RCSB], [http://www.ebi.ac.uk/pdbsum/4eq6 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eq6 OCA], [https://pdbe.org/4eq6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eq6 RCSB], [https://www.ebi.ac.uk/pdbsum/4eq6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eq6 ProSAT]</span></td></tr>
<table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/CSM2_YEAST CSM2_YEAST] Involved in chromosome segregation during meiosis. Promotes efficient recombinational repair and functions in the protection of the genome from spontaneous and induced DNA damage like mutations and gross chromosomal rearrangements (GCRs).<ref>PMID:11470404</ref> <ref>PMID:12972632</ref> <ref>PMID:15184655</ref> <ref>PMID:15654096</ref> <ref>PMID:19496932</ref>  
In Saccharomyces cerevisiae, four proteins, Shu1, Shu2, Psy3 and Csm2, form a stable SHU-complex both in vivo and in vitro. These proteins are involved in the early stages of the homologous recombination DNA damage repair process. In this paper, the crystal structure of the Psy3-Csm2 sub-complex is presented at 1.8A resolution and successfully fitted into our small angle X-ray scattering (SAXS) data of the SHU-complex. Taken together with our electrophoretic mobility shift assay (EMSA) results, a model is proposed for the SHU-protein complex coupled with DNA. STRUCTURED SUMMARY OF PROTEIN INTERACTIONS:: PSY3 and CSM2bind by X-ray crystallography (View interaction) PSY3, CSM2, Shu 1 and Shu 2physically interact by x ray scattering (View interaction).
 
Structural and SAXS analysis of the budding yeast SHU-complex proteins.,She Z, Gao ZQ, Liu Y, Wang WJ, Liu GF, Shtykova EV, Xu JH, Dong YH FEBS Lett. 2012 Jul 30;586(16):2306-12. Epub 2012 Jun 27. PMID:22749910<ref>PMID:22749910</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Saccharomyces cerevisiae]]
[[Category: Large Structures]]
[[Category: Dong, Y H.]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Gao, Z Q.]]
[[Category: Dong YH]]
[[Category: She, Z.]]
[[Category: Gao ZQ]]
[[Category: Dna binding protein]]
[[Category: She Z]]

Latest revision as of 08:50, 20 March 2024

The crystal structure of Psy3-Csm2 complex from budding yeast

4eq6, resolution 1.80Å

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