4a1w: Difference between revisions

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==Crystal structure of alpha-beta foldamer 4c in complex with Bcl-xL==
==Crystal structure of alpha-beta foldamer 4c in complex with Bcl-xL==
<StructureSection load='4a1w' size='340' side='right' caption='[[4a1w]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='4a1w' size='340' side='right'caption='[[4a1w]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4a1w]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A1W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A1W FirstGlance]. <br>
<table><tr><td colspan='2'>[[4a1w]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A1W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A1W FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=3FB:(3S)-3-AMINO-4-PHENYLBUTANOIC+ACID'>3FB</scene>, <scene name='pdbligand=B3E:(3S)-3-AMINOHEXANEDIOIC+ACID'>B3E</scene>, <scene name='pdbligand=B3Y:(3S)-3-AMINO-4-(4-HYDROXYPHENYL)BUTANOIC+ACID'>B3Y</scene>, <scene name='pdbligand=BIL:(3R,4S)-3-AMINO-4-METHYLHEXANOIC+ACID'>BIL</scene>, <scene name='pdbligand=HT7:(3S)-3-AMINO-4-(1H-INDOL-3-YL)BUTANOIC+ACID'>HT7</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.497&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4a1u|4a1u]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3FB:(3S)-3-AMINO-4-PHENYLBUTANOIC+ACID'>3FB</scene>, <scene name='pdbligand=B3E:(3S)-3-AMINOHEXANEDIOIC+ACID'>B3E</scene>, <scene name='pdbligand=B3Y:(3S)-3-AMINO-4-(4-HYDROXYPHENYL)BUTANOIC+ACID'>B3Y</scene>, <scene name='pdbligand=BIL:(3R,4S)-3-AMINO-4-METHYLHEXANOIC+ACID'>BIL</scene>, <scene name='pdbligand=HT7:(3S)-3-AMINO-4-(1H-INDOL-3-YL)BUTANOIC+ACID'>HT7</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a1w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a1w RCSB], [http://www.ebi.ac.uk/pdbsum/4a1w PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a1w OCA], [https://pdbe.org/4a1w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a1w RCSB], [https://www.ebi.ac.uk/pdbsum/4a1w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a1w ProSAT]</span></td></tr>
<table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>  Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4a1w" style="background-color:#fffaf0;"></div>
==See Also==
*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Boersma, M D.]]
[[Category: Large Structures]]
[[Category: Clarke, O B.]]
[[Category: Synthetic construct]]
[[Category: Colman, P M.]]
[[Category: Boersma MD]]
[[Category: Fairlie, W D.]]
[[Category: Clarke OB]]
[[Category: Gellman, S H.]]
[[Category: Colman PM]]
[[Category: Haase, H S.]]
[[Category: Fairlie WD]]
[[Category: Horne, W S.]]
[[Category: Gellman SH]]
[[Category: Kaufman, K J.]]
[[Category: Haase HS]]
[[Category: Lee, E F.]]
[[Category: Horne WS]]
[[Category: Smith, B J.]]
[[Category: Kaufman KJ]]
[[Category: Apoptosis-inhibitor complex]]
[[Category: Lee EF]]
[[Category: Mimicry]]
[[Category: Smith BJ]]
Retrieved from "https://proteopedia.org/4a1w"