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==Crystal structure of a Raver1 PRI4 peptide in complex with polypyrimidine tract binding protein RRM2==
==Crystal structure of a Raver1 PRI4 peptide in complex with polypyrimidine tract binding protein RRM2==
<StructureSection load='3zzz' size='340' side='right' caption='[[3zzz]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
<StructureSection load='3zzz' size='340' side='right'caption='[[3zzz]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3zzz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZZZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZZZ FirstGlance]. <br>
<table><tr><td colspan='2'>[[3zzz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZZZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZZZ FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1qm9|1qm9]], [[1sjr|1sjr]], [[2adb|2adb]], [[2ad9|2ad9]], [[2adc|2adc]], [[2evz|2evz]], [[1sjq|1sjq]], [[1wi6|1wi6]], [[3zzy|3zzy]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zzz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zzz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zzz RCSB], [http://www.ebi.ac.uk/pdbsum/3zzz PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zzz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zzz OCA], [https://pdbe.org/3zzz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zzz RCSB], [https://www.ebi.ac.uk/pdbsum/3zzz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zzz ProSAT]</span></td></tr>
<table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PTBP1_HUMAN PTBP1_HUMAN] Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10.<ref>PMID:11003644</ref> <ref>PMID:15009664</ref> <ref>PMID:16260624</ref> <ref>PMID:21518792</ref> <ref>PMID:16179478</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 3zzz" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Curry, S.]]
[[Category: Curry S]]
[[Category: Joshi, A.]]
[[Category: Joshi A]]
[[Category: Kotik-Kogan, O.]]
[[Category: Kotik-Kogan O]]
[[Category: Peptide binding]]
[[Category: Protein binding]]
[[Category: Rna recognition motif]]
Retrieved from "https://proteopedia.org/3zzz"