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==Structure of Dengue virus DIII in complex with Fab 2H12==
==Structure of Dengue virus DIII in complex with Fab 2H12==
<StructureSection load='4ala' size='340' side='right' caption='[[4ala]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
<StructureSection load='4ala' size='340' side='right'caption='[[4ala]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4ala]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_3 Dengue virus 3] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ALA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ALA FirstGlance]. <br>
<table><tr><td colspan='2'>[[4ala]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_3 Dengue virus 3] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ALA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ALA FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.84&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4al8|4al8]], [[4am0|4am0]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ala FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ala OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ala RCSB], [http://www.ebi.ac.uk/pdbsum/4ala PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ala FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ala OCA], [https://pdbe.org/4ala PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ala RCSB], [https://www.ebi.ac.uk/pdbsum/4ala PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ala ProSAT]</span></td></tr>
<table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q7TGD1_9FLAV Q7TGD1_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4ala" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Dengue virus 3]]
[[Category: Dengue virus 3]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Flanagan, A.]]
[[Category: Flanagan A]]
[[Category: Grimes, J M.]]
[[Category: Grimes JM]]
[[Category: Midgley, C M.]]
[[Category: Midgley CM]]
[[Category: Mongkolsapaya, J.]]
[[Category: Mongkolsapaya J]]
[[Category: Screaton, G R.]]
[[Category: Screaton GR]]
[[Category: Antibody]]
[[Category: Immune system]]
[[Category: Neutralisation]]
Retrieved from "https://proteopedia.org/4ala"