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==Co-crystal structure of WT 5-epi-Aristolochene synthase from Nicotiana tobaccum with geraniline==
==Co-crystal structure of WT 5-epi-Aristolochene synthase from Nicotiana tobaccum with geraniline==
<StructureSection load='4di5' size='340' side='right' caption='[[4di5]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='4di5' size='340' side='right'caption='[[4di5]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4di5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Nicotiana_tabacum Nicotiana tabacum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DI5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DI5 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4di5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Nicotiana_tabacum Nicotiana tabacum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DI5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DI5 FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1GA:GERANILINE'>1GA</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=DPO:DIPHOSPHATE'>DPO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">5-EAS, EAS3, EAS4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4097 Nicotiana tabacum])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1GA:GERANILINE'>1GA</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=DPO:DIPHOSPHATE'>DPO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5-epiaristolochene_synthase 5-epiaristolochene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.61 4.2.3.61] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4di5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4di5 OCA], [https://pdbe.org/4di5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4di5 RCSB], [https://www.ebi.ac.uk/pdbsum/4di5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4di5 ProSAT]</span></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4di5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4di5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4di5 RCSB], [http://www.ebi.ac.uk/pdbsum/4di5 PDBsum]</span></td></tr>
</table>
<table>
== Function ==
[https://www.uniprot.org/uniprot/5EAS_TOBAC 5EAS_TOBAC] Catalyzes the cyclization of trans,trans-farnesyl diphosphate (FPP) to the bicyclic intermediate 5-epi-aristolochene, initial step in the conversion of FPP to the sesquiterpenoid antifungal phytoalexin capsidiol. Produces germacrene A as an enzyme-bound intermediate that is not released by the enzyme, but is further cyclized to produce the bicyclic 5-epi-aristolochene.
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: 5-epiaristolochene synthase]]
[[Category: Large Structures]]
[[Category: Nicotiana tabacum]]
[[Category: Nicotiana tabacum]]
[[Category: Crenshaw, C M.]]
[[Category: Crenshaw CM]]
[[Category: Noel, J P.]]
[[Category: Noel JP]]
[[Category: Starks, C.]]
[[Category: Starks C]]
[[Category: All helical]]
[[Category: Inhibitor]]
[[Category: Lyase-lyase inhibitor complex]]
[[Category: Pyrophosphate]]
[[Category: Tea]]
Retrieved from "https://proteopedia.org/4di5"