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==SOLUTION NMR STRUCTURE OF THE GAGA FACTOR/DNA COMPLEX, 50 STRUCTURES==
==SOLUTION NMR STRUCTURE OF THE GAGA FACTOR/DNA COMPLEX, 50 STRUCTURES==
<StructureSection load='1yuj' size='340' side='right' caption='[[1yuj]], [[NMR_Ensembles_of_Models | 50 NMR models]]' scene=''>
<StructureSection load='1yuj' size='340' side='right'caption='[[1yuj]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1yuj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YUJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YUJ FirstGlance]. <br>
<table><tr><td colspan='2'>[[1yuj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YUJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YUJ FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1yui|1yui]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yuj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yuj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yuj RCSB], [http://www.ebi.ac.uk/pdbsum/1yuj PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yuj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yuj OCA], [https://pdbe.org/1yuj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yuj RCSB], [https://www.ebi.ac.uk/pdbsum/1yuj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yuj ProSAT]</span></td></tr>
<table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GAGA_DROME GAGA_DROME] Transcriptional activator that functions by regulating chromatin structure. Overcomes the repressive effects of chromatin by promoting the open chromatin conformation in promoter gene regions, thereby allowing access to other transcription factors. Binds to DNA Polycomb response elements (PREs) at the bithorax complex and to the proximal region of the engrailed promoter, and positively regulates transcription of many genes including homeotic ones. Binds to the DNA sequence (GA)n, with optimal binding to the pentamer 5'-GAGAG-3'. Binds DNA as an oligomer. May also act as a transcriptional repressor, maintaining the repressed state of genes including lolal, and down-regulating its own transcription. Required for dosage compensation in males and may be involved in oogenesis. Also has a role in nuclear division.<ref>PMID:7504178</ref> <ref>PMID:9241251</ref> <ref>PMID:8620838</ref> <ref>PMID:12200449</ref> <ref>PMID:12815073</ref> <ref>PMID:12834867</ref> <ref>PMID:15063171</ref> <ref>PMID:15020425</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 1yuj" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
[[Category: Clore, G M.]]
[[Category: Large Structures]]
[[Category: Gronenborn, A M.]]
[[Category: Clore GM]]
[[Category: Omichinski, J G.]]
[[Category: Gronenborn AM]]
[[Category: Chromatin remodeling]]
[[Category: Omichinski JG]]
[[Category: Dna binding protein-dna complex]]
Retrieved from "https://proteopedia.org/1yuj"