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==A High Resolution Crystal Structure of [d(CGCAAATTTGCG)]2==
==A High Resolution Crystal Structure of [d(CGCAAATTTGCG)]2==
<StructureSection load='1s2r' size='340' side='right' caption='[[1s2r]], [[Resolution|resolution]] 1.53&Aring;' scene=''>
<StructureSection load='1s2r' size='340' side='right'caption='[[1s2r]], [[Resolution|resolution]] 1.53&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1s2r]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S2R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1S2R FirstGlance]. <br>
<table><tr><td colspan='2'>[[1s2r]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S2R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S2R FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SPM:SPERMINE'>SPM</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.53&#8491;</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s2r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1s2r RCSB], [http://www.ebi.ac.uk/pdbsum/1s2r PDBsum]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SPM:SPERMINE'>SPM</scene></td></tr>
<table>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s2r OCA], [https://pdbe.org/1s2r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s2r RCSB], [https://www.ebi.ac.uk/pdbsum/1s2r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s2r ProSAT]</span></td></tr>
<div style="background-color:#fffaf0;">
</table>
== Publication Abstract from PubMed ==
The crystal structure of [d(CGCAAATTTGCG)]2 has been determined to 1.5 A resolution, representing the first high-resolution structure of this DNA fragment. The ion interactions are novel. A spermine molecule replaces a Mg2+ observed in analogous structures. Unlike lower-resolution structures, the minor groove is narrow and the major groove lacks extra Watson-Crick hydrogen bonds. In addition, a monolayer of solvent sites, including a "spine of hydration", is visible in the minor groove. The crystal of [d(CGCAAATTTGCG)]2 was grown from a solution containing spermine, magnesium, and lithium. The conformation recapitulates that of "monovalent-minus" DNA.
 
High-resolution structure of an extended A-tract: [d(CGCAAATTTGCG)]2.,Woods KK, Maehigashi T, Howerton SB, Sines CC, Tannenbaum S, Williams LD J Am Chem Soc. 2004 Dec 1;126(47):15330-1. PMID:15563130<ref>PMID:15563130</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Howerton, S B.]]
[[Category: Large Structures]]
[[Category: Maehigashi, T.]]
[[Category: Howerton SB]]
[[Category: Tannenbaum, S.]]
[[Category: Maehigashi T]]
[[Category: Williams, L D.]]
[[Category: Tannenbaum S]]
[[Category: Woods, K K.]]
[[Category: Williams LD]]
[[Category: Dna]]
[[Category: Woods KK]]
[[Category: Dodecamer]]
[[Category: Minor groove hydration]]

Latest revision as of 08:27, 14 February 2024

A High Resolution Crystal Structure of [d(CGCAAATTTGCG)]2

1s2r, resolution 1.53Å

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