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==Crystal structure of a complex of the ribosome large subunit with rapamycin==
==Crystal structure of a complex of the ribosome large subunit with rapamycin==
<StructureSection load='1z58' size='340' side='right' caption='[[1z58]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
<StructureSection load='1z58' size='340' side='right'caption='[[1z58]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1z58]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z58 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z58 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1z58]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z58 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z58 FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RAP:RAPAMYCIN+IMMUNOSUPPRESSANT+DRUG'>RAP</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ond|1ond]], [[1p9x|1p9x]], [[1nkw|1nkw]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RAP:RAPAMYCIN+IMMUNOSUPPRESSANT+DRUG'>RAP</scene></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z58 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z58 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z58 RCSB], [http://www.ebi.ac.uk/pdbsum/1z58 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z58 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z58 OCA], [https://pdbe.org/1z58 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z58 RCSB], [https://www.ebi.ac.uk/pdbsum/1z58 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z58 ProSAT]</span></td></tr>
<table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
RNA protection experiments and the crystal structure of a complex of the large ribosomal subunit from the eubacterium Deinococcus radiodurans with rapamycin, a polyketide compound resembling macrolides and ketolides, showed that rapamycin binds to a crevice located at the boundaries of the nascent protein exit tunnel, near its entrance. At this location rapamycin cannot occlude the ribosome exit tunnel, consistent with its failure to act as a ribosomal antibiotic drug. In accord with recent biochemical data, this crevice may play a role in facilitating local cotranslational folding of nascent chains, in particular for transmembrane proteins.
 
A crevice adjoining the ribosome tunnel: hints for cotranslational folding.,Amit M, Berisio R, Baram D, Harms J, Bashan A, Yonath A FEBS Lett. 2005 Jun 13;579(15):3207-13. Epub 2005 Mar 23. PMID:15943964<ref>PMID:15943964</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
==See Also==
</div>
*[[Ribosome 3D structures|Ribosome 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Deinococcus radiodurans]]
[[Category: Deinococcus radiodurans]]
[[Category: Amit, M.]]
[[Category: Large Structures]]
[[Category: Baram, D.]]
[[Category: Amit M]]
[[Category: Bashan, A.]]
[[Category: Baram D]]
[[Category: Berisio, R.]]
[[Category: Bashan A]]
[[Category: Harms, J.]]
[[Category: Berisio R]]
[[Category: Yonath, A.]]
[[Category: Harms J]]
[[Category: Polyketyde]]
[[Category: Yonath A]]
[[Category: Ribosome]]
[[Category: Tunnel]]
Retrieved from "https://proteopedia.org/1z58"