1bm9: Difference between revisions

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[[Image:1bm9.jpg|left|200px]]


{{Structure
==REPLICATION TERMINATOR PROTEIN FROM BACILLUS SUBTILIS==
|PDB= 1bm9 |SIZE=350|CAPTION= <scene name='initialview01'>1bm9</scene>, resolution 2.00&Aring;
<StructureSection load='1bm9' size='340' side='right'caption='[[1bm9]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[1bm9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BM9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BM9 FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
|GENE= RTP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bm9 OCA], [https://pdbe.org/1bm9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bm9 RCSB], [https://www.ebi.ac.uk/pdbsum/1bm9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bm9 ProSAT]</span></td></tr>
}}
</table>
== Function ==
[https://www.uniprot.org/uniprot/RTP_BACSU RTP_BACSU] Plays a role in DNA replication and termination (fork arrest mechanism). Two dimers of rtp bind to the two inverted repeat regions (IRI and IRII) present in the termination site. The binding of each dimer is centered on an 8 bp direct repeat.


'''REPLICATION TERMINATOR PROTEIN FROM BACILLUS SUBTILIS'''
==See Also==
 
*[[Replication Termination Protein|Replication Termination Protein]]
 
__TOC__
==Overview==
</StructureSection>
The crystal structure of the replication terminator protein (RTP) of B. subtilis has been determined at 2.6 A resolution. As previously suggested by both biochemical and biophysical studies, the molecule exists as a symmetric dimer and is in the alpha + beta protein-folding class. The protein has several uncommon features, including an antiparallel coiled-coil, which serves as the dimerization domain, and both an alpha-helix and a beta-ribbon suitably positioned to interact with the major and minor grooves of B-DNA. A site has been identified on the surface of RTP that is biochemically and positionally suitable for interaction with the replication-specific helicase. Other features of the structure are consistent with the polar contrahelicase mechanism of the protein. A model of the interaction between RTP and its cognate DNA is presented.
 
==About this Structure==
1BM9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BM9 OCA].
 
==Reference==
Crystal structure of the replication terminator protein from B. subtilis at 2.6 A., Bussiere DE, Bastia D, White SW, Cell. 1995 Feb 24;80(4):651-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7867072 7867072]
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Bastia, D.]]
[[Category: Bastia D]]
[[Category: Bussiere, D E.]]
[[Category: Bussiere DE]]
[[Category: White, S.]]
[[Category: White S]]
[[Category: contrahelicase]]
[[Category: dna-binding protein]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:12:58 2008''

Latest revision as of 06:37, 7 February 2024

REPLICATION TERMINATOR PROTEIN FROM BACILLUS SUBTILIS

1bm9, resolution 2.00Å

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