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==Phosphatidylinositol 4-kinase III beta-PIK93 in a complex with Rab11a- GTP gammaS==
==Phosphatidylinositol 4-kinase III beta-PIK93 in a complex with Rab11a- GTP gammaS==
<StructureSection load='4d0l' size='340' side='right' caption='[[4d0l]], [[Resolution|resolution]] 2.94&Aring;' scene=''>
<StructureSection load='4d0l' size='340' side='right'caption='[[4d0l]], [[Resolution|resolution]] 2.94&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4d0l]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D0L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D0L FirstGlance]. <br>
<table><tr><td colspan='2'>[[4d0l]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D0L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D0L FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=093:N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)-+PHENYLTHIAZOLE-2-YL)-ACETAMIDE'>093</scene>, <scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.94&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4d0m|4d0m]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=093:N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)-+PHENYLTHIAZOLE-2-YL)-ACETAMIDE'>093</scene>, <scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/1-phosphatidylinositol_4-kinase 1-phosphatidylinositol 4-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.67 2.7.1.67] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d0l OCA], [https://pdbe.org/4d0l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d0l RCSB], [https://www.ebi.ac.uk/pdbsum/4d0l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d0l ProSAT]</span></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d0l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4d0l RCSB], [http://www.ebi.ac.uk/pdbsum/4d0l PDBsum]</span></td></tr>
</table>
<table>
== Function ==
[https://www.uniprot.org/uniprot/PI4KB_HUMAN PI4KB_HUMAN] Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity).<ref>PMID:9405935</ref> <ref>PMID:10559940</ref> <ref>PMID:12749687</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4d0l" style="background-color:#fffaf0;"></div>
==See Also==
*[[Phosphatidylinositol 4-kinase|Phosphatidylinositol 4-kinase]]
*[[Ras-related protein Rab 3D structures|Ras-related protein Rab 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: 1-phosphatidylinositol 4-kinase]]
[[Category: Homo sapiens]]
[[Category: Burke, J E.]]
[[Category: Large Structures]]
[[Category: Inglis, A J.]]
[[Category: Burke JE]]
[[Category: Masson, G R.]]
[[Category: Inglis AJ]]
[[Category: McLaughin, S H.]]
[[Category: Masson GR]]
[[Category: Perisic, O.]]
[[Category: McLaughin SH]]
[[Category: Rutaganira, F.]]
[[Category: Perisic O]]
[[Category: Shokat, K M.]]
[[Category: Rutaganira F]]
[[Category: Williams, R L.]]
[[Category: Shokat KM]]
[[Category: Golgi]]
[[Category: Williams RL]]
[[Category: Gtp]]
[[Category: Gtpase]]
[[Category: Nucleotide]]
[[Category: Phosphatidylinositol 4-kinase]]
[[Category: Phosphoinositide]]
[[Category: Pi4k]]
[[Category: Pi4kb]]
[[Category: Pi4p]]
[[Category: Pik93]]
[[Category: Ptdins4p]]
[[Category: Rab11]]
[[Category: Recycling endosome]]
[[Category: Signal transduction]]
[[Category: Signaling]]
[[Category: Transferase]]
[[Category: Transferase-hydrolase complex]]
Retrieved from "https://proteopedia.org/4d0l"