4tlj: Difference between revisions

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'''Unreleased structure'''


The entry 4tlj is ON HOLD
==Ultra-high resolution crystal structure of caprine Beta-lactoglobulin==
<StructureSection load='4tlj' size='340' side='right'caption='[[4tlj]], [[Resolution|resolution]] 1.17&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4tlj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Capra_hircus Capra hircus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TLJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TLJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.17&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BU1:1,4-BUTANEDIOL'>BU1</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tlj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tlj OCA], [https://pdbe.org/4tlj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tlj RCSB], [https://www.ebi.ac.uk/pdbsum/4tlj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tlj ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LACB_CAPHI LACB_CAPHI] Primary component of whey, it binds retinol and is probably involved in the transport of that molecule.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
beta-Lactoglobulin (betalg) is the most abundant whey protein in the milks of ruminant animals. While bovine betalg has been subjected to a vast array of studies, little is known about the caprine ortholog. We present an ultra-high resolution crystal structure of caprine betalg complemented by analytical ultracentrifugation and small-angle X-ray scattering data. In both solution and crystalline states caprine betalg is dimeric (KD&lt;5muM); however, our data suggest a flexible quaternary arrangement of subunits within the dimer. These structural findings will provide insight into relationships among structural, processing, nutritional and immunological characteristics that distinguish cow's and goat's milk.


Authors: Crowther, J.M., Jameson, G.B., Suzuki, H., Dobson, R.C.J.
Ultra-high resolution crystal structure of recombinant caprine beta-lactoglobulin.,Crowther JM, Lasse M, Suzuki H, Kessans SA, Loo TS, Norris GE, Hodgkinson AJ, Jameson GB, Dobson RC FEBS Lett. 2014 Sep 18. pii: S0014-5793(14)00685-1. doi:, 10.1016/j.febslet.2014.09.010. PMID:25241165<ref>PMID:25241165</ref>


Description: Ultra-high resolution crystal structure of caprine Beta-lactoglobulin
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4tlj" style="background-color:#fffaf0;"></div>
 
==See Also==
*[[Beta-lactoglobulin 3D structures|Beta-lactoglobulin 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Capra hircus]]
[[Category: Large Structures]]
[[Category: Crowther JM]]
[[Category: Dobson RCJ]]
[[Category: Jameson GB]]
[[Category: Suzuki H]]
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