4d2m: Difference between revisions
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==Vaccinia Virus F1L bound to Bim BH3== | ==Vaccinia Virus F1L bound to Bim BH3== | ||
<StructureSection load='4d2m' size='340' side='right' caption='[[4d2m]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='4d2m' size='340' side='right'caption='[[4d2m]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4d2m]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D2M OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[4d2m]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Vaccinia_virus_Ankara Vaccinia virus Ankara]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D2M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D2M FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | ||
<tr><td class="sblockLbl"><b>[[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d2m OCA], [https://pdbe.org/4d2m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d2m RCSB], [https://www.ebi.ac.uk/pdbsum/4d2m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d2m ProSAT]</span></td></tr> | |||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </table> | ||
<table> | == Function == | ||
[https://www.uniprot.org/uniprot/PG045_VACCA PG045_VACCA] Plays a role in evading host innate immune response by inhibiting host inflammasome activation. Interacts with and inhibits NLR-mediated interleukin-1 beta/IL1B production in infected cells. At the host mitochondria outer membrane, interacts with the BH3 domain of host BAK and prevents BAK from binding active BAX. In turn, host apoptosis is inhibited.[UniProtKB:P24356] | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4d2m" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Vaccinia virus Ankara]] | ||
[[Category: Colman PM]] | |||
[[Category: Kvansakul M]] | |||
