4pkm: Difference between revisions
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==Crystal Structure of Bacillus thuringiensis Cry51Aa1 Protoxin at 1.65 Angstroms Resolution== | |||
<StructureSection load='4pkm' size='340' side='right'caption='[[4pkm]], [[Resolution|resolution]] 1.65Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4pkm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_thuringiensis_F14-1 Bacillus thuringiensis F14-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PKM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PKM FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pkm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pkm OCA], [https://pdbe.org/4pkm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pkm RCSB], [https://www.ebi.ac.uk/pdbsum/4pkm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pkm ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/A7IZR5_BACTU A7IZR5_BACTU] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The structures of several Bacillus thuringiensis (Bt) insecticidal crystal proteins have been determined by crystallographic methods and a close relationship has been explicated between specific toxicities and conserved three-dimensional architectures. In this study, as a representative of the coleopteran- and hemipteran-specific Cry51A group, the complete structure of Cry51Aa1 protoxin has been determined by X-ray crystallography at 1.65 A resolution. This is the first report of a coleopteran-active Bt insecticidal toxin with high structural similarity to the aerolysin-type beta-pore forming toxins (beta-PFTs). Moreover, study of featured residues and structural elements reveal their possible roles in receptor binding and pore formation events. This study provides new insights into the action of aerolysin-type beta-PFTs from a structural perspective, and could be useful for the control of coleopteran and hemipteran insect pests in agricultures. | |||
Crystal structure of Cry51Aa1: A potential novel insecticidal aerolysin-type beta-pore-forming toxin from Bacillus thuringiensis.,Xu C, Chinte U, Chen L, Yao Q, Meng Y, Zhou D, Bi LJ, Rose J, Adang MJ, Wang BC, Yu Z, Sun M Biochem Biophys Res Commun. 2015 May 7. pii: S0006-291X(15)00758-5. doi:, 10.1016/j.bbrc.2015.04.068. PMID:25957471<ref>PMID:25957471</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 4pkm" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Bacillus thuringiensis F14-1]] | |||
[[Category: Large Structures]] | |||
[[Category: Bi LJ]] | |||
[[Category: Chen L]] | |||
[[Category: Chinte U]] | |||
[[Category: Li L]] | |||
[[Category: Meng Y]] | |||
[[Category: Rose J]] | |||
[[Category: Sun M]] | |||
[[Category: Wang BC]] | |||
[[Category: Xu C]] | |||
[[Category: Yao Q]] | |||
[[Category: Yu Z]] | |||
[[Category: Zhou D]] | |||
Latest revision as of 00:45, 28 December 2023
Crystal Structure of Bacillus thuringiensis Cry51Aa1 Protoxin at 1.65 Angstroms Resolution
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