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==Ec_IspH in complex with 4-oxopentyl diphosphate==
==Ec_IspH in complex with 4-oxopentyl diphosphate==
<StructureSection load='3utd' size='340' side='right' caption='[[3utd]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='3utd' size='340' side='right'caption='[[3utd]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3utd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UTD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UTD FirstGlance]. <br>
<table><tr><td colspan='2'>[[3utd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UTD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UTD FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0CJ:4-OXOPENTYL+TRIHYDROGEN+DIPHOSPHATE'>0CJ</scene>, <scene name='pdbligand=F3S:FE3-S4+CLUSTER'>F3S</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ke8|3ke8]], [[3dnf|3dnf]], [[3urk|3urk]], [[3utc|3utc]], [[3uv3|3uv3]], [[3uv6|3uv6]], [[3uv7|3uv7]], [[3uv8|3uv8]], [[3uwm|3uwm]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0CJ:4-OXOPENTYL+TRIHYDROGEN+DIPHOSPHATE'>0CJ</scene></td></tr>
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ispH, lytB, yaaE, b0029, JW0027 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3utd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3utd OCA], [https://pdbe.org/3utd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3utd RCSB], [https://www.ebi.ac.uk/pdbsum/3utd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3utd ProSAT]</span></td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxy-3-methylbut-2-enyl_diphosphate_reductase 4-hydroxy-3-methylbut-2-enyl diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.1.2 1.17.1.2] </span></td></tr>
</table>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3utd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3utd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3utd RCSB], [http://www.ebi.ac.uk/pdbsum/3utd PDBsum]</span></td></tr>
== Function ==
<table>
[https://www.uniprot.org/uniprot/ISPH_ECOLI ISPH_ECOLI] Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Is also involved in penicillin tolerance and control of the stringent response. Seems to directly or indirectly interact with RelA to maintain it in an inactive form during normal growth.<ref>PMID:19569147</ref> <ref>PMID:20080550</ref> <ref>PMID:22137895</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 3utd" style="background-color:#fffaf0;"></div>
==See Also==
*[[4-hydroxy-3-methylbut-2-enyl diphosphate reductase 3D structures|4-hydroxy-3-methylbut-2-enyl diphosphate reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase]]
[[Category: Escherichia coli K-12]]
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Bacher, A.]]
[[Category: Bacher A]]
[[Category: Eisenreich, W.]]
[[Category: Eisenreich W]]
[[Category: Groll, M.]]
[[Category: Groll M]]
[[Category: Oldfield, E.]]
[[Category: Oldfield E]]
[[Category: Schulz, C.]]
[[Category: Schulz C]]
[[Category: Span, I.]]
[[Category: Span I]]
[[Category: Wang, K.]]
[[Category: Wang K]]
[[Category: Wang, W.]]
[[Category: Wang W]]
[[Category: Zhang, Y.]]
[[Category: Zhang Y]]
[[Category: Iron-sulfur protein]]
[[Category: Isoprenoid biosynthesis]]
[[Category: Isph]]
[[Category: Lytb]]
[[Category: Non-mevalonate pathway]]
[[Category: Oxidoreductase]]