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| | | <StructureSection load='3q9o' size='400' side='right' caption='Structure of Vibrio cholerae exotoxin complex with NAD and glycerol (PDB code [[3q9o]]).' scene='59/593276/Cv/1'> |
| <StructureSection load='3q9o' size='340' side='right' caption='Structure of ''Vibrio cholerae'' exotoxin complex with inhibitor (PDB code [[3q9o]]).' scene=''> | |
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| == Function == | | == Function == |
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| Exotoxins (ET) are toxins which are secreted by bacteria. | | Exotoxins (ET) are toxins which are secreted by Gram-positive and Gram-negative bacteria<ref>PMID:17675409</ref>. ETs are heat labile. They are highly toxic and fatal in μg quantities. ETs bind to specific receptors and have no enzymatic activity. |
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| == Disease == | | == Relevance == |
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| == Relevance ==
| | Exotoxins are involved in tetanus, diphtheria and botulism. |
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| == Structural highlights == | | == Structural highlights == |
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| | <scene name='59/593276/Cv/4'>NAD binding site</scene> in ''Vibrio cholerae'' exotoxin (PDB code [[3q9o]]).<ref>PMID:22535961</ref> Water molecules shown as red spheres. |
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| ==3D structures of exotoxin== | | ==3D structures of exotoxin== |
| | [[Exotoxin 3D structures]] |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | </StructureSection> |
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| ===''Pseudomonas aeruginosa'' exotoxin===
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| [[1ikq]] – PaET A <br />
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| [[1ikp]] – PaET A (mutant) <br />
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| [[1dma]] – PaET A catalytic domain + nicotinamide + AMP <br />
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| [[1aer]] – PaET A catalytic domain + NAD analog + AMP <br />
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| [[1xk9]] – PaET A catalytic domain + inhibitor <br />
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| [[1zm2]] – PaET A catalytic domain + diphthamide + adenosine diphosphoribose + EF-2 <br />
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| [[1zm3]] – PaET A catalytic domain + diphthamide + EF-2 <br />
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| [[3b78]], [[2zit]] – PaET A catalytic domain + diphthamide + NAD + EF-2 <br />
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| [[3b82]], [[3b8h]] – PaET A catalytic domain (mutant) + diphthamide + NAD + EF-2 <br />
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| [[1zm4]] – PaET A catalytic domain + diphthamide + NAD analog + EF-2 <br />
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| [[1zm9]] – PaET A catalytic domain + diphthamide + inhibitor + EF-2 <br />
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| ===''Vibrio cholerae'' exotoxin===
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| [[2q5t]] – VcET <br />
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| [[2q6m]], [[3ess]], [[3ki0]], [[3ki1]], [[3ki2]], [[3ki3]], [[3ki4]], [[3ki5]], [[3ki6]], [[3ki7]], [[3ny6]] – VcET catalytic domain + inhibitor <br />
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| [[3q9o]] – VcET + inhibitor <br />
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| ===''Streptococcus pyogenes'' exotoxin===
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| [[1b1z]], [[1fnu]], [[1fnv]], [[1fnw]] – SpET A1 <br />
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| [[1dki]] – SpET B<br />
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| [[2jtc]] – SpET B (mutant) - NMR<br />
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| [[1an8]] – SpET C<br />
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| [[1et9]] – SpET H<br />
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| [[1ty0]] – SpET J<br />
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| [[1ha5]], [[1uup]] – SpET A1 + Zn<br />
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| [[1l0x]] – SpET A1 (mutant) + T cell receptor β chain<br />
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| [[1pvj]] – SpET B + inhibitor <br />
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| [[2uzj]] – SpET B + guanidine derivative <br />
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| [[1eu4]] – SpET H + Zn<br />
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| [[1ty2]] – SpET J + Zn<br />
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| [[1ktk]] – SpET C (mutant) + T cell receptor β chain<br />
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| [[1l0y]] – SpET A1 (mutant) + T cell receptor β chain + Zn<br />
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| [[1hqr]] – SpRT C + antibody + myelin basic protein<br />
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| ===''Staphylococcus aureus'' exotoxin===
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| [[1v1o]], [[1v1p]] – SaET 1 <br />
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| [[2r61]], [[2z8l]] – SaET 3<br />
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| [[3o13]] – SaET 15<br />
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| [[3kls]] – SaET 1 (mutant) + complement C5<br />
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| ===''Corynebacterium diphtheriae'' exotoxin===
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| See [[Diphtheria toxin]]
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| == References == | | == References == |
