Choline kinase: Difference between revisions

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New page: <StructureSection load='2ckp' size='340' side='right' caption='Structure of human choline kinase α2 complex with phosphocholine (PDB code 2ckp). ' scene=''> == Function == '''Choli...
 
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<StructureSection load='2ckq' size='340' side='right' caption='Structure of human choline kinase α2 complex with phosphocholine (PDB code [[2ckq]]). ' scene='59/593958/Cv/1'>
<StructureSection load='2ckp' size='340' side='right' caption='Structure of human choline kinase α2 complex with phosphocholine (PDB code [[2ckp]]). ' scene=''>


== Function ==
== Function ==
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== Structural highlights ==
== Structural highlights ==
The choline binds to CK in a <scene name='59/593958/Cv/5'>deep hydrophobic groove</scene> (PDB code [[2ckq]]; {{Template:ColorKey_Hydrophobic}},  {{Template:ColorKey_Polar}}) and the <scene name='59/593958/Cv/6'>ADP binds in a cleft</scene> (PDB code [[2ckp]]). <ref>PMID:17007874</ref>


==3D structures of choline kinase==
==3D structures of choline kinase==
[[Choline kinase 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
 
[[2i7q]] – hCK α – human<br />
[[2cko]] – hCK α2 <br />
 
===Choline kinase complexes===
 
[[2ckp]] – hCK α2 + ADP<br />
[[2ckp]] – hCK α2 + phosphocholine<br />
[[3zm9]], [[4da5]], [[4br3]] – hCK α + inhibitor<br />
[[3f2r]] – hCK α + hemicholinium-3<br />
[[3g15]] – hCK α + hemicholinium-3 + ADP<br />
[[4cg8]], [[4cg9]], [[4cga]] – hCK α1 + bispyridinium derivative<br />
 
 


== References ==
== References ==