4qqv: Difference between revisions
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New page: '''Unreleased structure''' The entry 4qqv is ON HOLD Authors: Jackson, C.J., Young, I.G., Murphy, J.M., Carr, P.D., Ewens, C.L., Dai, J., Ollis, D.L. Description: Extracellular domains... |
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==Extracellular domains of mouse IL-3 beta receptor== | |||
<StructureSection load='4qqv' size='340' side='right'caption='[[4qqv]], [[Resolution|resolution]] 3.45Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4qqv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QQV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QQV FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.45Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qqv OCA], [https://pdbe.org/4qqv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qqv RCSB], [https://www.ebi.ac.uk/pdbsum/4qqv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qqv ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/IL3B2_MOUSE IL3B2_MOUSE] In mouse, there are two classes of high-affinity IL3 receptors. One contains this IL3-specific beta subunit and the other contains the beta subunit also shared by high-affinity IL5 and GM-CSF receptors. | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Interleukin-3 (IL-3) is a cytokine secreted by mast cells and activated T-cells known to be an important regulator of differentiation, survival, proliferation and activation of a range of hematopoietic lineages. The effects of IL-3 on target cells are mediated by a transmembrane receptor system composed of a cytokine-specific alpha-subunit and a beta-subunit, the principal signalling entity. In the mouse, two beta-subunits have co-evolved: a common beta-subunit (betac) shared between IL-3 and the related cytokines, IL-5 and GM-CSF; and an IL-3-specific beta-subunit (betaIL-3). betaIL3 differs from betac in its specificity for IL-3 and its capacity to bind IL-3 directly in the absence of an alpha-subunit and, in the absence of structural information, the basis for these properties has remained enigmatic. Here, we present the crystal structure of the betaIL-3 ectodomain at 3.45 A resolution. This structure provides the first evidence that betaIL-3 adopts an arch-shaped, intertwined homodimer with similar topology to the paralogous betac structure. In contrast to apo-betac, however, the ligand-binding interface of betaIL3 appears to pre-exist in a conformation receptive to IL-3 engagement. Molecular modelling of the IL-3:betaIL3 interface, in conjunction with previous mutational studies, suggests that divergent evolution of both betaIL3 and IL-3 underlies their unique capacity for direct interaction and specificity. | |||
Crystal structure of the mouse interleukin-3 beta-receptor: insights into interleukin3 binding and receptor activation.,Carr PD, Ewens CL, Dai J, Ollis DL, Murphy JM, Jackson CJ, Young IG Biochem J. 2014 Aug 19. PMID:25137390<ref>PMID:25137390</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 4qqv" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Interleukin receptor 3D structures|Interleukin receptor 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Carr PD]] | |||
[[Category: Dai J]] | |||
[[Category: Ewens CL]] | |||
[[Category: Jackson CJ]] | |||
[[Category: Murphy JM]] | |||
[[Category: Ollis DL]] | |||
[[Category: Young IG]] | |||
