4qr4: Difference between revisions
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New page: '''Unreleased structure''' The entry 4qr4 is ON HOLD Authors: Xiong,B., Cao,D.Y., Chen,T.T., Xu,Y.C. Description: Brd4 Bromodomain 1 complex with its novel inhibitors |
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==Brd4 Bromodomain 1 complex with its novel inhibitors== | |||
<StructureSection load='4qr4' size='340' side='right'caption='[[4qr4]], [[Resolution|resolution]] 1.28Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4qr4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QR4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QR4 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.28Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BNK:2-CHLORO-N-CYCLOPENTYL-5-(2-OXO-2,3-DIHYDRO-1,3-THIAZOL-4-YL)BENZENESULFONAMIDE'>BNK</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qr4 OCA], [https://pdbe.org/4qr4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qr4 RCSB], [https://www.ebi.ac.uk/pdbsum/4qr4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qr4 ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | |||
==See Also== | |||
*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Cao DY]] | |||
[[Category: Chen TT]] | |||
[[Category: Xiong B]] | |||
[[Category: Xu YC]] | |||
Latest revision as of 08:59, 20 March 2024
Brd4 Bromodomain 1 complex with its novel inhibitors
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