4m1c: Difference between revisions

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'''Unreleased structure'''


The entry 4m1c is ON HOLD  until Aug 06 2015
==Crystal Structure Analysis of Fab-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Amyloid-Beta (1-40)==
<StructureSection load='4m1c' size='340' side='right'caption='[[4m1c]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4m1c]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M1C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M1C FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5007&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m1c OCA], [https://pdbe.org/4m1c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m1c RCSB], [https://www.ebi.ac.uk/pdbsum/4m1c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m1c ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref>


Authors: McCord, L.M., Liang, W., Farcasanu, M., Scherpelz, K., Meredith, S.C., Koide, S., Tang, W.J.
==See Also==
 
*[[Insulin-degrading enzyme 3D structures|Insulin-degrading enzyme 3D structures]]
Description: Crystal Structure Analysis of Fab-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Amyloid-Beta (1-40)
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Farcasanu M]]
[[Category: Koide S]]
[[Category: Liang W]]
[[Category: McCord LM]]
[[Category: Meredith SC]]
[[Category: Scherpelz K]]
[[Category: Tang WJ]]
Retrieved from "https://proteopedia.org/4m1c"