4twk: Difference between revisions

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'''Unreleased structure'''


The entry 4twk is ON HOLD
==Crystal structure of human two pore domain potassium ion channel TREK1 (K2P2.1)==
<StructureSection load='4twk' size='340' side='right'caption='[[4twk]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4twk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TWK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TWK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=37X:OCTYL+GLUCOSE+NEOPENTYL+GLYCOL'>37X</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4twk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4twk OCA], [https://pdbe.org/4twk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4twk RCSB], [https://www.ebi.ac.uk/pdbsum/4twk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4twk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KCNK2_HUMAN KCNK2_HUMAN] Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner.<ref>PMID:10784345</ref> <ref>PMID:24196565</ref> <ref>PMID:11319556</ref>  Isoform 4: Does not display channel activity but reduces the channel activity of isoform 1 and isoform 2 and reduces cell surface expression of isoform 2 (By similarity).<ref>PMID:10784345</ref> <ref>PMID:24196565</ref> <ref>PMID:11319556</ref>


Authors: Pike, A.C.W, Dong, Y.Y., Tessitore, A., Goubin, S., Strain-Damerell, C., Mukhopadhyay, S., Kupinska, K., Wang, D., Chalk, R., Berridge, G., Grieben, M., Shrestha, L., Ang, J.H., Mackenzie, A., Quigley, A., Bushell, S.R., Shintre, C.A., Faust, B., Chu, A., Dong, L., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Burgess-Brown, N., Carpenter, E.P.
==See Also==
 
*[[Potassium channel 3D structures|Potassium channel 3D structures]]
Description: Crystal structure of human two pore domain potassium ion channel TREK1 (K2P2.1)
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Ang JH]]
[[Category: Arrowsmith CH]]
[[Category: Berridge G]]
[[Category: Bountra C]]
[[Category: Burgess-Brown NA]]
[[Category: Bushell SR]]
[[Category: Carpenter EP]]
[[Category: Chalk R]]
[[Category: Chu A]]
[[Category: Dong L]]
[[Category: Dong YY]]
[[Category: Edwards AM]]
[[Category: Faust B]]
[[Category: Goubin S]]
[[Category: Grieben M]]
[[Category: Kupinska K]]
[[Category: Mackenzie A]]
[[Category: Mukhopadhyay S]]
[[Category: Pike ACW]]
[[Category: Quigley A]]
[[Category: Shintre CA]]
[[Category: Shrestha L]]
[[Category: Strain-Damerell C]]
[[Category: Tessitore A]]
[[Category: Wang D]]
[[Category: Von Delft F]]
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