4u0l: Difference between revisions
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New page: '''Unreleased structure''' The entry 4u0l is ON HOLD Authors: Xiang, Y., Zhu, D.Y. Description: Structure of a GTP binding protein (double mutant) |
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==Structure of the Vibrio cholerae di-nucleotide cyclase (DncV) mutant D131A-D133A== | |||
<StructureSection load='4u0l' size='340' side='right'caption='[[4u0l]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4u0l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae_O1_biovar_El_Tor_str._N16961 Vibrio cholerae O1 biovar El Tor str. N16961]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U0L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U0L FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u0l OCA], [https://pdbe.org/4u0l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u0l RCSB], [https://www.ebi.ac.uk/pdbsum/4u0l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u0l ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/DNCV_VIBCH DNCV_VIBCH] Catalyzes the synthesis of cyclic AMP-GMP from ATP and GTP. Is also able to produce c-di-AMP and c-di-GMP from ATP and GTP, respectively; however, c-AMP-GMP is the dominant molecule produced by DncV in vivo. Is required for efficient V.cholerae intestinal colonization, and down-regulates the colonization-influencing process of chemotaxis. Is not active with dATP, TTP, UTP, and CTP. | |||
==See Also== | |||
*[[Cyclic GMP-AMP synthase 3D synthase|Cyclic GMP-AMP synthase 3D synthase]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Vibrio cholerae O1 biovar El Tor str. N16961]] | |||
[[Category: Xiang Y]] | |||
[[Category: Zhu DY]] | |||