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==CRYSTAL STRUCTURE AND STABILITY OF A DNA DUPLEX CONTAINING A(ANTI).G(SYN) BASE-PAIRS==
==CRYSTAL STRUCTURE AND STABILITY OF A DNA DUPLEX CONTAINING A(ANTI).G(SYN) BASE-PAIRS==
<StructureSection load='111d' size='340' side='right' caption='[[111d]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
<StructureSection load='111d' size='340' side='right'caption='[[111d]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[111d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=111D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=111D FirstGlance]. <br>
<table><tr><td colspan='2'>[[111d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=111D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=111D FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=111d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=111d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=111d RCSB], [http://www.ebi.ac.uk/pdbsum/111d PDBsum]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
<table>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=111d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=111d OCA], [https://pdbe.org/111d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=111d RCSB], [https://www.ebi.ac.uk/pdbsum/111d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=111d ProSAT]</span></td></tr>
<div style="background-color:#fffaf0;">
</table>
== Publication Abstract from PubMed ==
The synthetic dodecanucleotide d(CGCAAATTGGCG) has been analysed by single-crystal X-ray diffraction techniques and the structure refined to R = 0.16 and 2.25 A resolution, with the location of 94 solvent molecules. The sequence crystallizes as a full turn of a B-DNA helix with ten Watson-Crick base-pairs and two adenine-guanine mispairs. The analysis clearly shows that the mismatches are of the form A(anti).G(syn). Thermal denaturation studies indicate that the stability of the duplex is strongly pH dependent, with a maximum at pH 5.0, suggesting that the base-pair is stabilized by protonation. Three different arrangements have been observed for base-pairs between guanine and adenine and it is likely that A.G mismatch conformation is strongly influenced by dipole-dipole interactions with adjacent base-pairs.
 
Crystal structure and stability of a DNA duplex containing A(anti).G(syn) base-pairs.,Brown T, Leonard GA, Booth ED, Chambers J J Mol Biol. 1989 May 20;207(2):455-7. PMID:2754734<ref>PMID:2754734</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Booth, E D.]]
[[Category: Large Structures]]
[[Category: Brown, T.]]
[[Category: Booth ED]]
[[Category: Chambers, J.]]
[[Category: Brown T]]
[[Category: Leonard, G A.]]
[[Category: Chambers J]]
[[Category: B-dna]]
[[Category: Leonard GA]]
[[Category: Dna]]
[[Category: Double helix]]
[[Category: Mismatched]]
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