4u3y: Difference between revisions
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New page: '''Unreleased structure''' The entry 4u3y is ON HOLD Authors: Harris, S.F., Wu, P., Coons, M. Description: Apo Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) |
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==Apo Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4)== | |||
<StructureSection load='4u3y' size='340' side='right'caption='[[4u3y]], [[Resolution|resolution]] 1.45Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4u3y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U3Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U3Y FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u3y OCA], [https://pdbe.org/4u3y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u3y RCSB], [https://www.ebi.ac.uk/pdbsum/4u3y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u3y ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/M4K4_HUMAN M4K4_HUMAN] Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322.<ref>PMID:9890973</ref> <ref>PMID:21690388</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Coons M]] | |||
[[Category: Harris SF]] | |||
[[Category: Wu P]] | |||
Latest revision as of 00:49, 28 December 2023
Apo Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4)
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