4utq: Difference between revisions
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New page: ==A structural model of the active ribosome-bound membrane protein insertase YidC== <StructureSection load='4utq' size='340' side='right' caption='4utq, resolution 8.00&... |
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==A structural model of the active ribosome-bound membrane protein insertase YidC== | ==A structural model of the active ribosome-bound membrane protein insertase YidC== | ||
< | <SX load='4utq' size='340' side='right' viewer='molstar' caption='[[4utq]], [[Resolution|resolution]] 8.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4utq]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4utq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UTQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UTQ FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 8Å</td></tr> | ||
<table> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4utq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4utq OCA], [https://pdbe.org/4utq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4utq RCSB], [https://www.ebi.ac.uk/pdbsum/4utq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4utq ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/YIDC_ECOLI YIDC_ECOLI] Inner membrane protein required for the insertion and/or proper folding and/or complex formation of integral inner membrane proteins. Involved in integration of membrane proteins that insert dependently and independently of the Sec translocase complex, as well as at least 2 lipoproteins. Its own insertion requires SRP and is Sec translocase-dependent. Essential for the integration of Sec-dependent subunit a of the F(0)ATP synthase, FtsQ and SecE proteins and for Sec-independent subunit c of the F(0)ATP synthase, M13 phage procoat and the N-terminus of leader peptidase Lep. Probably interacts directly with Sec-independent substrates. Sec-dependent protein FtsQ interacts first with SecY then subsequently with YidC. Sec-dependent LacY and MalF require YidC to acquire tertiary structure and stability, a chaperone-like function, but not for membrane insertion. Stable maltose transport copmplex formation (MalFGK(2)) also requires YidC. Partially complements a Streptococcus mutans yidC2 disruption mutant.<ref>PMID:10675323</ref> <ref>PMID:10949305</ref> <ref>PMID:12724529</ref> <ref>PMID:12950181</ref> <ref>PMID:15140892</ref> <ref>PMID:15067017</ref> <ref>PMID:17073462</ref> <ref>PMID:18456666</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4utq" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[ATPase 3D structures|ATPase 3D structures]] | |||
*[[Insertase|Insertase]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</ | </SX> | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Andreani | [[Category: Large Structures]] | ||
[[Category: Beckmann | [[Category: Andreani J]] | ||
[[Category: Berninghausen | [[Category: Beckmann R]] | ||
[[Category: Bischoff | [[Category: Berninghausen O]] | ||
[[Category: Schulten | [[Category: Bischoff L]] | ||
[[Category: Seemayer | [[Category: Schulten K]] | ||
[[Category: Singharoy | [[Category: Seemayer S]] | ||
[[Category: Soeding | [[Category: Singharoy A]] | ||
[[Category: Wickles | [[Category: Soeding J]] | ||
[[Category: VanderSluis | [[Category: Wickles S]] | ||
[[Category: VanderSluis EO]] | |||
