4uq8: Difference between revisions

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'''Unreleased structure'''


The entry 4uq8 is ON HOLD
==Electron cryo-microscopy of bovine Complex I==
<SX load='4uq8' size='340' side='right' viewer='molstar' caption='[[4uq8]], [[Resolution|resolution]] 4.95&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4uq8]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UQ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UQ8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.95&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uq8 OCA], [https://pdbe.org/4uq8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uq8 RCSB], [https://www.ebi.ac.uk/pdbsum/4uq8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uq8 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Complex I (NADH:ubiquinone oxidoreductase) is essential for oxidative phosphorylation in mammalian mitochondria. It couples electron transfer from NADH to ubiquinone with proton translocation across the energy-transducing inner membrane, providing electrons for respiration and driving ATP synthesis. Mammalian complex I contains 44 different nuclear- and mitochondrial-encoded subunits, with a combined mass of 1 MDa. The 14 conserved 'core' subunits have been structurally defined in the minimal, bacterial complex, but the structures and arrangement of the 30 'supernumerary' subunits are unknown. Here we describe a 5 A resolution structure of complex I from Bos taurus heart mitochondria, a close relative of the human enzyme, determined by single-particle electron cryo-microscopy. We present the structures of the mammalian core subunits that contain eight iron-sulphur clusters and 60 transmembrane helices, identify 18 supernumerary transmembrane helices, and assign and model 14 supernumerary subunits. Thus, we considerably advance knowledge of the structure of mammalian complex I and the architecture of its supernumerary ensemble around the core domains. Our structure provides insights into the roles of the supernumerary subunits in regulation, assembly and homeostasis, and a basis for understanding the effects of mutations that cause a diverse range of human diseases.


Authors: Vinothkumar, K.R., Zhu, J., Hirst, J.
Architecture of mammalian respiratory complex I.,Vinothkumar KR, Zhu J, Hirst J Nature. 2014 Sep 7. doi: 10.1038/nature13686. PMID:25209663<ref>PMID:25209663</ref>


Description: Electron cryo-microscopy of bovine ComplexI
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4uq8" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</SX>
[[Category: Bos taurus]]
[[Category: Large Structures]]
[[Category: Hirst J]]
[[Category: Vinothkumar KR]]
[[Category: Zhu J]]
Retrieved from "https://proteopedia.org/4uq8"