4cri: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
 
(4 intermediate revisions by the same user not shown)
Line 1: Line 1:
==Crystal Structure of 53BP1 tandem tudor domains in complex with methylated K810 Rb peptide==
==Crystal Structure of 53BP1 tandem tudor domains in complex with methylated K810 Rb peptide==
<StructureSection load='4cri' size='340' side='right' caption='[[4cri]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
<StructureSection load='4cri' size='340' side='right'caption='[[4cri]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4cri]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CRI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CRI FirstGlance]. <br>
<table><tr><td colspan='2'>[[4cri]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CRI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CRI FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cri FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cri OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cri RCSB], [http://www.ebi.ac.uk/pdbsum/4cri PDBsum]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
<table>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cri FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cri OCA], [https://pdbe.org/4cri PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cri RCSB], [https://www.ebi.ac.uk/pdbsum/4cri PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cri ProSAT]</span></td></tr>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein.  
[https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref> <ref>PMID:17190600</ref>
[https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref> <ref>PMID:17190600</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 18: Line 20:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4cri" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Arrowsmith, C H.]]
[[Category: Homo sapiens]]
[[Category: Bountra, C.]]
[[Category: Large Structures]]
[[Category: Carr, S.]]
[[Category: Arrowsmith CH]]
[[Category: Crawley, L.]]
[[Category: Bountra C]]
[[Category: Delft, F von.]]
[[Category: Carr S]]
[[Category: Edwards, A.]]
[[Category: Crawley L]]
[[Category: Fedorov, O.]]
[[Category: Edwards A]]
[[Category: Gileadi, C.]]
[[Category: Fedorov O]]
[[Category: Johansson, C.]]
[[Category: Gileadi C]]
[[Category: Krojer, T.]]
[[Category: Johansson C]]
[[Category: Oppermann, U.]]
[[Category: Krojer T]]
[[Category: Thangue, N B.La.]]
[[Category: La Thangue NB]]
[[Category: Vollmar, M.]]
[[Category: Oppermann U]]
[[Category: 53bp1]]
[[Category: Vollmar M]]
[[Category: Peptide binding protein]]
[[Category: Von Delft F]]
[[Category: Tumour suppressor prb]]
Retrieved from "https://proteopedia.org/4cri"