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==Electrostatics of Active Site Microenvironments of E. coli DHFR==
==Electrostatics of Active Site Microenvironments of E. coli DHFR==
<StructureSection load='4p66' size='340' side='right' caption='[[4p66]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
<StructureSection load='4p66' size='340' side='right'caption='[[4p66]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4p66]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P66 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P66 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4p66]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P66 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P66 FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.84&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=XCN:S-CYANO-L-CYSTEINE'>XCN</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=XCN:S-CYANO-L-CYSTEINE'>XCN</scene></td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4p68|4p68]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p66 OCA], [https://pdbe.org/4p66 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p66 RCSB], [https://www.ebi.ac.uk/pdbsum/4p66 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p66 ProSAT]</span></td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
</table>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p66 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p66 RCSB], [http://www.ebi.ac.uk/pdbsum/4p66 PDBsum]</span></td></tr>
== Function ==
<table>
[https://www.uniprot.org/uniprot/C3TR70_ECOLX C3TR70_ECOLX] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4p66" style="background-color:#fffaf0;"></div>
==See Also==
*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Dihydrofolate reductase]]
[[Category: Escherichia coli]]
[[Category: Asbury, J B.]]
[[Category: Large Structures]]
[[Category: Benkovic, S J.]]
[[Category: Asbury JB]]
[[Category: French, J B.]]
[[Category: Benkovic SJ]]
[[Category: Hammes-Schiffer, S.]]
[[Category: French JB]]
[[Category: Hanoian, P.]]
[[Category: Hammes-Schiffer S]]
[[Category: III, R J.Stewart.]]
[[Category: Hanoian P]]
[[Category: Layfield, J P.]]
[[Category: Layfield JP]]
[[Category: Liu, C T.]]
[[Category: Liu CT]]
[[Category: Catalysis]]
[[Category: Stewart III RJ]]
[[Category: Catalytic cycle]]
[[Category: Electrostatic]]
[[Category: Oxidoreductase]]
Retrieved from "https://proteopedia.org/4p66"